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COMT Val158Met polymorphism is related with interpersonal problem solving in schizophrenia

Published online by Cambridge University Press:  16 April 2020

A. Üçok ,
M. Öztürk ,
Z. Duman  and
G. Saruhan-Direskeneli
A. Üçok*
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Millet Street, Capa, 34390Istanbul, Turkey
M. Öztürk
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Millet Street, Capa, 34390Istanbul, Turkey
Z. Duman
Affiliation:
Dokuz Eylul University, School of Nursing, Izmir, Turkey
G. Saruhan-Direskeneli
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey
*
*E-mail address: [email protected] (A. Üçok).
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Abstract

Objective

The aim of this study was to investigate associations between COMT Val158Met polymorphism, and interpersonal problem solving capacity and cognitive functions in schizophrenia.

Methods

COMT Val158Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. Brief Psychiatric Rating Scale was used to assess symptom severity. The Assessment of Interpersonal Problem Solving Skills (AIPSS) was used to evaluate problem solving capacity. Continuous Performance Test (CPT) and Wisconsin Card Sorting Test (WCST), were used to measure cognition.

Results

Patients with Met/Met genotype had higher AIPSS subscores for detecting the problem, than those with Val/Val at baseline (p = 0.02). Met allele was also found to be related with higher AIPSS-receiving skills (p = 0.04). Val allele was found to be related with more commission errors in CPT (p = 0.03). There was no relation between Val158Met polymorphism and WCST and clinical measurements.

Conclusion

Our findings suggest that Val allele might be related to poor performance on detecting the interpersonal problems, and attention in schizophrenia.

Keywords

SchizophreniaCOMT Val158MetCognitionAttentionInterpersonal problem solving
Type
Psychiatric Genetics
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 320 - 322
Copyright
Copyright © Elsevier Masson SAS 2010

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