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The complex Impact of Five Years of Stress Related to Life-Threatening Events on Pregnancy Outcomes: A Preliminary Retrospective Study

Published online by Cambridge University Press:  15 April 2020

M. Keren ,
N. Keren ,
A. Eden ,
S. Tsangen ,
A. Weizman  and
G. Zalsman
M. Keren*
Affiliation:
Child and Adolescent Division, Geha Mental Health Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
N. Keren
Affiliation:
Child and Adolescent Division, Geha Mental Health Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A. Eden
Affiliation:
Barzilai Medical Center, Ashkelon, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
S. Tsangen
Affiliation:
Barzilai Medical Center, Ashkelon, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
A. Weizman
Affiliation:
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Research Unit, Geha Mental Health Center, Petah Tikva, Israel Felsenstein Medical Research Center, Petah Tikva, Israel
G. Zalsman
Affiliation:
Child and Adolescent Division, Geha Mental Health Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Molecular Imaging and Neuropathology Division, Psychiatry Department, Columbia University, New York, NY, USA
*
*Corresponding author. Infant Mental Health Unit, Geha Mental Health Center, P.O.B 102, Petah Tiqva, Israel. E-mail address:[email protected] (M. Keren).
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Abstract

Objective:

To study the impact of chronic, life-threatening stressors in the form of daily missile attacks, for five consecutive years, on pregnancy outcomes.

Method:

Charts of deliveries from two neighboring towns in the south of Israel, covering the years 2000 and 2003–2008, were reviewed retrospectively. One city had been exposed to missile attacks, while the other was not. For each year, 100 charts were chosen at random.

Results:

Significant association was found between exposure to stress and frequency of pregnancy complications (P = 0.047) and premature membrane rupture (P = 0.029). A more detailed analysis, based on dividing the stressful years into three distinct periods: early (2003–2004), intermediate (2005–2006) and late (2007–2008), revealed that preterm deliveries were significantly more frequent (P = 0.044) during the intermediate period, as was premature membrane rupture during the late period (P = 0.014).

Conclusion:

Exposure to chronic life-threatening stress resulted in more pregnancy complications and in particular more premature membrane ruptures. The impact was most significant during the middle period of the 5-year-exposure to the stressor. Hence it seems that factors of duration and habituation may play a role in the impact of chronic, life-threatening stressors on pregnancy.

Keywords

Chronic life-threatening stressPregnancy outcomeDifferential impact
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 2 , February 2015 , pp. 317 - 321
Copyright
Copyright © Elsevier Masson SAS 2014

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References

Barker, D.J.. In utero programming of chronic disease. Clin Sci 1998; 95 2: 115–128.CrossRefGoogle ScholarPubMed
Class, Q.A., Lichtenstein, P., Langstrom, N., D’Onofrio, B.M.. Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies. Psychosom Med 2011; 73 2: 234–241.CrossRefGoogle ScholarPubMed
Davis, E.P., Glynn, L.M., Dunkel-Schetter, C., Hobel, C., Chicz-Demet, A., Sandman, C.A.. Corticotropin-releasing hormone during pregnancy is associated with infant temperament. Dev Neurosci 2005; 27 2: 299–305.CrossRefGoogle ScholarPubMed
Davis, E.P., Glynn, L.M., Schetter, C.D., Hobel, C., Chicz-Demet, A., Sandman, C.A.. Prenatal exposure to maternal depression and cortisol influences infant temperament. J Am Acad Child Adolesc Psychiatry 2007; 46 2: 737–746.CrossRefGoogle ScholarPubMed
Diaz, R., Brown, R.W., Seckl, J.R.. Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions. J Neurosci 1998; 18 2: 2570–2580.CrossRefGoogle ScholarPubMed
Ghosh, J.K., Wilhelm, M.H., Dunkel-Schetter, C., Lombardi, C.A., Ritz, B.R.. Paternal support and preterm birth, and the moderation of effects of chronic stress: a study in Los Angeles county mothers. Arch Womens Ment Health 2010; 13 2: 327–338.CrossRefGoogle ScholarPubMed
Gluckman, P.D., Hanson, M.A.. Living with the past: evolution, development, and patterns of disease. Science 2004; 305 2: 1733–1736.CrossRefGoogle ScholarPubMed
Glynn, L.M., Wadhwa, P.D., Dunkel-Schetter, C., Chicz-Demet, A., Sandman, C.A.. When stress happens matters: effects of earthquake timing on stress responsivity in pregnancy. Am J Obstet Gynecol 2001; 184 2: 637–642.CrossRefGoogle ScholarPubMed
Grissom, N., Bhatnagar, S.. Habituation to repeated stress: get used to it. Neurobiol Learn Mem 2009; 92 2: 215–224.CrossRefGoogle Scholar
Koehl, M., Darnaudery, M., Dulluc, J., Van Reeth, O., Le Moal, M., Maccari, S.. Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender. J Neurobiol 1999; 40 2: 302–315.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Lederman, S.A., Rauh, V., Weiss, L., Stein, J.L., Hoepner, L.A., Becker, M., et al.The effects of the World Trade Center event on birth outcomes among term deliveries at three lower Manhattan hospitals. Environ Health Perspect 2004; 112 2: 1772–1778.CrossRefGoogle ScholarPubMed
Nathanielsz, P.W.Life in the womb: the origin of helath and disease. Ithaca, NY: Promethean; 1999.Google Scholar
Tegethoff, M., Greene, N., Olsen, J., Meyer, A.H., Meinlschmidt, G.Maternal psychosocial adversity during pregnancy is associated with length of gestation and offspring size at birth: evidence from a population-based cohort study. Psychosom Med 2010; 72 2: 419–426.CrossRefGoogle ScholarPubMed
Thompson, R.F., Spencer, W.A.Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol Rev 1966; 73 2: 16–43.CrossRefGoogle Scholar
Torche, F.The effect of maternal stress on birth outcomes: exploiting a natural experiment. Demography 2011; 48 2: 1473–1491.CrossRefGoogle ScholarPubMed
Wainstock, T., Lerner-Geva, L., Glasser, S., Shoham-Vardi, I., Anteby, E.Y.Prenatal stress and risk of spontaneous abortion. Psychosom Med 2013; 75 2: 228–235.CrossRefGoogle ScholarPubMed
Weinstock, M.The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun 2005; 19 2: 296–308.CrossRefGoogle ScholarPubMed
Zhu, P., Tao, F., Hao, J., Sun, Y., Jiang, X.Prenatal life events stress: implications for preterm birth and infant birth weight. Am J Obstet Gynecol 2010;203 2: [34e1-e8].CrossRefGoogle Scholar
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