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Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine

Published online by Cambridge University Press:  16 April 2020

A. Urban ,
J. Libiger ,
L. Hosák  and
K. Kupka
A. Urban*
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
J. Libiger
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
L. Hosák
Affiliation:
Department of Psychiatry, University Hospital, 500 05Hradec Králové, Czech Republic
K. Kupka
Affiliation:
Institute of Nuclear Medicine, Charles University, 1st School of Medicine, Prague, Czech Republic
*
2Corresponding author. [email protected]
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Abstract

Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS). We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS. Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain. A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way. This helped us to find a proper therapeutic strategy for our patient.

Keywords

SchizophreniaParkinsonismClozapineSPECT
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 258 - 259
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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