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Combining nefazodone and midazolam during ECT

Published online by Cambridge University Press:  16 April 2020

A. Conca ,
Z. Al-Dubai ,
P. König  and
W. Beraus
A. Conca
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
Z. Al-Dubai
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
P. König
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
W. Beraus
Affiliation:
Department of Psychiatry I, Regional Hospital Rankweil, LKH-Rankweil, Valdunastr. 16, 6830 Rankweil, Austria
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Summary

We report the case of a patient suffering from dysthymia. He underwent successful ECT treatment and was medicated with nefazodone and midazolam. Comparing the EEG and motor seizure duration in the periods with and without midazolam, no significant differences were recorded, but the dosage of thiopental and of succinylcholine had to be increased markedly after midazolam was discontinued (P < 0.05; ANOVA). This case indicates a substantial pharmacodynamic interaction between nefazodone, midazolam, thiopental, and succinylcholine.

Keywords

ETCmidazolamnefazodone
Type
Case report
Information
European Psychiatry , Volume 14 , Issue 6 , October 1999 , pp. 360 - 362
Copyright
Copyright © European Psychiatric Association 1999

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