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Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder

Published online by Cambridge University Press:  16 April 2020

M Moldavsky ,
D Stein ,
R Benatov ,
P Sirota ,
A Elizur ,
Y Matzner  and
A Weizman
M Moldavsky
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
D Stein
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
R Benatov
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
P Sirota
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Elizur
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Y Matzner
Affiliation:
Hematology Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
A Weizman
Affiliation:
Geha Psychiatric Hosvital and Felsenstein Medical Research Center, Beilinson Medical Campus, Petah Tiqva, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel
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Summary

Three adolescent and two adult patients suffering from chronic excited psychoses (either schizophrenia or schizoaffective disorder) resistant to traditional neuroleptics and clozapine were treated with combined clozapine-lithium. Improvement was assessed with the Positive and Negative Symptoms Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impressions, administered before and during combined clozapine-lithium treatment. All patients demonstrated a significant improvement with this combination. There was no occurrence of agranulocytosis, neuroleptic malignant syndrome or other clinically significant adverse effects.

Keywords

clozapinelithiumschizophreniaschizoaffective disorder
Type
Short communication
Information
European Psychiatry , Volume 13 , Issue 2 , 1998 , pp. 104 - 106
Copyright
Copyright © Elsevier, Paris 1998

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References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, FourthEdition. Washington, DC: American Psychiatric Association; 1994Google Scholar
Baldessarini, R, Frankenburg, F. Clozapine. A novel antipsychotic agent New Engl J Med 1991 ; 324(11) : 746-54Google ScholarPubMed
Boggs, DR, Joyce, RA. The hematopoietic effects of lithium Semin Hematol 1983; 20 : 129-38Google ScholarPubMed
Brotman, AW, Falk, WE, Gelenberg, AJ. Pharmacologic treatment of acute depressive subtypes In: Meltzer, HY ed. Psychopharmacology. The fhird genertrtion of progress. New York: Raven Press; 1987. p. 1038Google Scholar
Bryois, C, Ferrero, F. Clinical observation of 11 patients under clozapine-lithium association Eur Psychiatry 1993; 8 : 213-18CrossRefGoogle Scholar
Garcia, G, Crismon, ML, Dorson, PG. Seizures in two patients after the addition of lithium to a clozanine regimen J Clin Psychopharmacol 1994 ; 14(6) : 426-7Google ScholarPubMed
Gerson, SL. Clozapine - deciphering the risks N Engl J Med 1993 ; 329 : 204-5CrossRefGoogle ScholarPubMed
Guy, W. ECDEU Assessment Manual for Psychopharmacology Rockville: US Dept of Health and Human Services Publication (ADM); 1976. p 218-22Google Scholar
Hammond, WP, Dale, DC. Cyclic hematopoiesis: Effects of lithium on colony forming cells and colony stimulating activity in grey collie dogs Blood 1982 ; 59 : 179CrossRefGoogle ScholarPubMed
Hammond, WP, Rodger, ER, Dale, DC. Lithium augments GMCSA generation in canine cyclic hematopoiesis. Blood 1987 : 69: 117-23CrossRefGoogle ScholarPubMed
Kane, JM. Clinical efficacy of clozapine in treatment-refractory schizophrenia: An overview Br J Psychiatry 1992 ; 160 suppl 17 : 41-5CrossRefGoogle Scholar
Kane, JM, Honigfeld, G, Singer, J et al. Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine Arch Gen Psychiatry 1988 ; 45 : 789-96CrossRefGoogle ScholarPubMed
Kay, SG, Opler, LA, Lindenmayer, JP. Reliability and validity of the Positive and Negative Symptoms Scale for schizophrenia. Psychiatry Res 1988; 23 : 99–110CrossRefGoogle Scholar
Kay, SR, Wolkenfeld, F, Murrill, LM. Profiles of aggression among psychiatric patients J Nerv Ment Dis 1988 ; 176 : 547-57CrossRefGoogle ScholarPubMed
McGrath, HE, Liang, CM, Alberico, TA, Quesenberry, PJ. The effect of lithium on growth Factor production in long-term bone marrow cultures Blood 1987; 70 : 1136-42CrossRefGoogle ScholarPubMed
Naber, D, Holzbach, R, Perro, C, Hippius, H. Clinical management of clozapine patients in relation to efficacy and sideeffects Br J Psychiatry 1992 ; 160 suppl 17 : 54-9CrossRefGoogle Scholar
Overall, JE and Gorham, DR. The Brief Psychiatric Rating Scale Psychol Rep 1962 ; 1O : 799–812CrossRefGoogle Scholar
Pope, HG Jr, Cole, JO, Choras, PT, Fulwiler, CF. Apparent neuroleptic malignant syndrome with clozapine and lithium J Nerv Ment Dis 1986 ; 174(8) : 493-5CrossRefGoogle ScholarPubMed
Sandoz Pharma Ltd. Clozaril, new drug application East Hanover: Sandoz Pharma Ltd; 1987Google Scholar
Valevski, A, Modai, I, Lahav, M, Weizman, A. Clozapine-lithium combined treatment and agranulocytosis Int Clin Pharmacol 1993 ; 8 : 63-5Google ScholarPubMed
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