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Cognitive function and metabolic syndrome in unipolar and bipolar depression: A pilot study

Published online by Cambridge University Press:  13 August 2021

T. Jannini ,
L. Longo ,
F. Marasco ,
M. Di Civita ,
C. Niolu ,
A. Siracusano  and
G. Di Lorenzo
T. Jannini*
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
L. Longo
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
F. Marasco
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
M. Di Civita
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
C. Niolu
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
A. Siracusano
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
G. Di Lorenzo
Affiliation:
Department Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
*
*Corresponding author.

Abstract

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Introduction

Cognitive function is impaired in depressive disorders. Among several factors implicated in regulation of the cognitive function, metabolic syndrome has been showed have a pivotal role cognitive functioning in healthy controls. However, the role of metabolic syndrome in regulating the cognitive functioning of subjects affected by depressive disorders is little studied.

Objectives

To investigate the effect of metabolic syndrome in regulation of cognition in unipolar and bipolar depression.

Methods

One-hundred-sixty-five people affected by a depressive disorder (unipolar depression, UP; bipolar depression, BP) were enrolled at the Psychiatric and Clinic Psychology Unit of the University of Rome Tor Vergata, Rome, Italy. A group of healthy controls (HC) matched for agender and age was enrolled. The cognitive functions were evaluated with a computerized tool, THINC-it.

Results

UP and BP had lower performances in THINC-it cognitive domains than HC. Metabolic syndrome is a negative, independent predictor of low performance in the THINC-it cognitive domains of people with depressive disorders.

Conclusions

Our findings confirm that metabolic syndrome has a prominent role in determining the cognitive efficiency in depressive disorders, independently by the presence of a unipolar or bipolar depressive disorder. Metabolic syndrome has to be considered a major factor that should be considered in the treatment strategies of cognitive functioning improvement of people affected by depressive disorders.

Disclosure

No significant relationships.

Keywords

Metabolic syndromecognitive functionbipolar disordermajor depressive disorder
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S82
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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