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Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries

Published online by Cambridge University Press:  01 September 2022

A. Iznak ,
E. Iznak ,
I. Oleichik  and
S. Zozulya
A. Iznak*
Affiliation:
Mental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian Federation
E. Iznak
Affiliation:
Mental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian Federation
I. Oleichik
Affiliation:
Mental Health Research Centre, Department Of Endogenous Mental Disorders And Affective Conditions, Moscow, Russian Federation
S. Zozulya
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Non-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem.

Objectives

The aim of the study was to determine the relationships between pre-treatment quantitative clinical, EEG, and neuroimmunological parameters in female depressive adolescents with NSSI.

Methods

40 female depressive patients (all right-handed, 16–25 years old, mean 17.6±2.2 years old) were included in the study. Total HDRS-17 scores varied from 14 to 38 (mean 26.0±6.9). Multichannel eyes closed resting EEG was recorded with subsequent spectral power (SP) measurements in narrow frequency sub-bands. Enzymatic activities of leukocyte elastase (LE) and its antagonist α-1 proteinase inhibitor (α1-PI), as neuroinflammation markers, and the levels of autoantibodies to S100b protein (AAB-S100b) and to basic myelin protein (AAB-BMP), as neuroplasticity markers, were measured in the blood plasma. Spearman’s rank correlations were calculated between clinical, EEG, and neuroimmunological parameters.

Results

HDRS-17 scores correlated positively (p<0.05) with beta2 (20-30 Hz) SP in the right anterior and mid-temporal leads. AAB-S100b values correlated positively with alpha2 (9-11 Hz) and alpha3 (11-13 Hz) SP in central-temporal-parietal-occipital leads, and correlated negatively with beta1 (13-20 Hz) and beta2 SP in the right anterior temporal lead.

Conclusions

The structure of clinical–neurobiological correlations obtained indicates that processes of neuroinflammation in depressive adolescents with NSSI are relatively mild and/or compensated by anti-inflammatory mechanisms. The study supported by RBRF grant No.20-013-00129a.

Disclosure

No significant relationships.

Keywords

Adolescentsnon-suicidal self-injuriesquantitative EEGneuroimmunology
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S325
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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