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Clinical observation of 11 patients under clozapine-lithium association

Published online by Cambridge University Press:  16 April 2020

C Bryois  and
F Ferrero
C Bryois
Affiliation:
Clinique psychiatrique universitaire, CH-1008Prilly, France
F Ferrero
Affiliation:
Clinique psychiatrique universitaire, CH-1008Prilly, France
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Summary

Ten men and one woman aged 27 to 52 years and presenting chronic evolution of their psychotic disorders benefited from a treatment which associated lithium sulfate at a plasmatic level of 0.5 to 0.8 meq/L with clozapine (mean posology: 300 mg/day). Five patients presented chronic disorganized schizophrenia (295.14), five a schizoaffective disorder (295.70) and one patient chronic undifferentiated schizophrenia (295.94) according to DSM III-R. Nine of the eleven patients showed mood disorders in addition to their psychotic and dissociative symptomatology. The remaining two presented chronic disorganised schizophrenia with aggressive behaviour. The clozapine-lithium association led to stabilization and improvement in the condition of all patients. Nine patients are still undergoing treatment with satisfactory results. The mean duration of the clozapine-lithium treatment, which has proved to be well tolerated with regard to side-effects, is about five years.

Keywords

lithium-clozapine associationschizophreniamood disorder
Type
Short communication
Information
European Psychiatry , Volume 8 , Issue 4 , 1993 , pp. 213 - 218
Copyright
Copyright © Elsevier, Paris 1993

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