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Clinical and neuropsychological differences in schizophrenia according to negative symptom PANSS scores

Published online by Cambridge University Press:  16 April 2020

M.A. Jimenez-Arriero
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
R. Rodriguez-Jimenez
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
G. Rubio
Affiliation:
Mental Health Services, Retiro, Madrid, Spain
I. Martinez
Affiliation:
Mental Health Services, Retiro, Madrid, Spain
M. Aragues
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
A. Koeneke
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
A. Bagney
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
P. Carretero
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
G. Ponce
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
T. Palomo
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain

Abstract

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Background and aims:

The Positive and Negative Syndrome Scale (PANSS) evaluates different psychopathological aspects of schizophrenic patients. Scores on the negative subscale of the PANSS have been associated with clinical and neuropsychological differences in these patients. Our aim was to study the relationship between PANSS negative scores and different clinical and neuropsychological variables in a sample of schizophrenic patients.

Methods:

Our sample of 174 schizophrenic patients was split into two groups according to scores on the negative subscale of the PANSS: a group of 85 patients (55 male and 30 female; mean age 38.0 years, SD 9.3) with scores below the median (“low negative PANSS” group), and a group of 89 patients (58 male and 31 female; mean age 37.3, SD 8.4) with scores above the median (“high negative PANSS” group). The neuropsychological task used was the Wisconsin Card Sorting Test.

Results:

Significant clinical differences were found between both groups. In the “high negative PANSS” group a lower age of illness onset was found (p=0.030), as well as a lower age at first psychiatric admission (p=0.002) compared to the “low negative PANSS” group, without there being significant differences in current age (p=0.570). Regarding cognitive functions, “high negative PANSS” patients achieved fewer categories (p=0.005) and made more perseverative errors (p=0.031) than “low negative PANSS” patients.

Conclusions:

Schizophrenic patients with higher scores on the negative subscale of the PANSS had an earlier age of onset of their illness and exhibited poorer cognitive functioning than patients with lower scores.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Copyright
Copyright © European Psychiatric Association 2007
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