Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-17T05:17:43.323Z Has data issue: false hasContentIssue false
  • English
  • Français

Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder

Published online by Cambridge University Press:  16 April 2020

S. Dallaspezia ,
C. Lorenzi ,
A. Pirovano ,
C. Colombo ,
E. Smeraldi  and
F. Benedetti
S. Dallaspezia*
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
C. Lorenzi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
A. Pirovano
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
C. Colombo
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
E. Smeraldi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
F. Benedetti
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
*
*Corresponding author. Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, San Raffaele Turro, Via Stamira d'Ancona 20, Milano, Italy. Tel.: +39 02 26433156; fax: +39 02 26433265. E-mail address: [email protected] (S. Dallaspezia).
Get access

Abstract

Postpartum depression can mark the onset of bipolar disorder. The coding region of Per3 gene contains a variable-number tandem-repeat polymorphism, which has been shown to influence bipolar disorder onset and to affect breast cancer risk. We showed a relationship between Per3 polymorphism and postpartum depressive onset in bipolar disorder.

Keywords

Postpartum depressionBipolar disorderClock genesPer3 gene VNTR polymorphism
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 3 , April 2011 , pp. 138 - 140
Copyright
Copyright © Elsevier Masson SAS 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. revised. Washington DC: American Psychiatric Association; 2002.Google Scholar
Archer, SN, Robilliard, DL, Skene, DJ, Smits, M, Williams, A, Arendt, J, et al.A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 2003; 26: 413–415.CrossRefGoogle ScholarPubMed
Benedetti, F, Dallaspezia, S, Colombo, C, Pirovano, A, Marino, E, Smeraldi, EA length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett 2008; 445: 184–187.Google ScholarPubMed
Bloch, M, Daly, RC, Rubinow, DREndocrine factors in the etiology of postpartum depression. Compr Psychiatry 2003; 44: 234–246.CrossRefGoogle ScholarPubMed
Bloch, M, Schmidt, PJ, Danaceau, M, Murphy, J, Nieman, L, Rubinow, DREffects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 2000; 157: 924–930.CrossRefGoogle ScholarPubMed
Calcagni, E, Elenkov, IStress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann N Y Acad Sci 2006; 1069: 62–76.CrossRefGoogle Scholar
Coryell, W, Solomon, D, Turvey, C, Keller, M, Leon, AC, Endicott, J, et al.The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 2003; 60: 914–920.Google ScholarPubMed
Crowe, RR, Smouse, PEThe genetic implications of age-dependent penetrance in manic-depressive illness. J Psychiatr Res 1977; 13: 273–285.CrossRefGoogle ScholarPubMed
Dallaspezia, S, Benedetti, FMelatonin, circadian rhythms, and the clock genes in bipolar disorder. Curr Psychiatry Rep 2009; 11: 488–493.CrossRefGoogle ScholarPubMed
Dijk, DJ, Archer, SNPERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med Rev 2010; 14: 151–160.CrossRefGoogle ScholarPubMed
Dorheim, SK, Bondevik, GT, Eberhard-Gran, M, Bjorvatn, BSleep and depression in postpartum women: a population-based study. Sleep 2009; 32: 847–855.CrossRefGoogle ScholarPubMed
Drevets, WC, Todd, RDDepression, mania and related disorders.Rubin, EZorumsk, CAdult psychiatry Oxford: Blackwell Publishing; 2005.Google Scholar
Ebisawa, T, Uchiyama, M, Kajimura, N, Mishima, K, Kamei, Y, Katoh, M, et al.Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep 2001; 2: 342–346.CrossRefGoogle ScholarPubMed
Friedman, SHPostpartum mood disorders: genetic progress and treatment paradigms. Am J Psychiatry 2009; 166: 1201–1204.CrossRefGoogle ScholarPubMed
Galea, LA, Wide, JK, Barr, AMEstradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behav Brain Res 2001; 122: 1–9.Google Scholar
Gery, S, Virk, RK, Chumakov, K, Yu, A, Koeffler, HPThe clock gene Per2 links the circadian system to the estrogen receptor. Oncogene 2007; 26: 7916–7920.CrossRefGoogle ScholarPubMed
Ghaemi, SN, Ko, JY, Goodwin, FKCade's disease” and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. Can J Psychiatry 2002; 47: 125–134.CrossRefGoogle Scholar
Goel, N, Banks, S, Mignot, E, Dinges, DFPER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One 4 2009 e5874CrossRefGoogle Scholar
Goyal, D, Gay, CL, Lee, KAPatterns of sleep disruption and depressive symptoms in new mothers. J Perinat Neonatal Nurs 2007; 21: 123–129.CrossRefGoogle ScholarPubMed
Guess, J, Burch, JB, Ogoussan, K, Armstead, CA, Zhang, H, Wagner, S, et al.Circadian disruption. Per3, and human cytokine secretion. Integr Cancer Ther 2009; 8: 329–336.CrossRefGoogle ScholarPubMed
Malkesman, O, Austin, DR, Chen, G, Manji, HKReverse translational strategies for developing animal models of bipolar disorder. Dis Model Mech 2009; 2: 238–245.CrossRefGoogle ScholarPubMed
Nievergelt, CM, Kripke, DF, Barrett, TB, Burg, E, Remick, RA, Sadovnick, AD, et al.Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 234–241.CrossRefGoogle ScholarPubMed
Osterlund, MKUnderlying mechanisms mediating the antidepressant effects of estrogens. Biochim Biophys Acta 2010; 1800: 1136–1144.CrossRefGoogle ScholarPubMed
Pawluski, JL, Charlier, TD, Lieblich, SE, Hammond, GL, Galea, LAReproductive experience alters corticosterone and CBG levels in the rat dam. Physiol Behav 2009; 96: 108–114.CrossRefGoogle ScholarPubMed
Shearman, LP, Jin, X, Lee, C, Reppert, SM, Weaver, DRTargeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol 2000; 20: 6269–6275.CrossRefGoogle ScholarPubMed
Shearman, LP, Sriram, S, Weaver, DR, Maywood, ES, Chaves, I, Zheng, B, et al.Interacting molecular loops in the mammalian circadian clock. Science 2000; 288: 1013–1019.CrossRefGoogle ScholarPubMed
Skalkidou, A, Sylven, SM, Papadopoulos, FC, Olovsson, M, Larsson, A, Sundstrom-Poromaa, IRisk of postpartum depression in association with serum leptin and interleukin-6 levels at delivery: a nested case-control study within the UPPSAT cohort. Psychoneuroendocrinology 2009; 34: 1329–1337.CrossRefGoogle ScholarPubMed
Takumi, T, Taguchi, K, Miyake, S, Sakakida, Y, Takashima, N, Matsubara, C, et al.A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. EMBO J 1998; 17: 4753–4759.CrossRefGoogle ScholarPubMed
Viola, AU, Archer, SN, James, LM, Groeger, JA, Lo, JC, Skene, DJ, et al.PER3 polymorphism predicts sleep structure and waking performance. Curr Biol 2007; 17: 613–618.CrossRefGoogle ScholarPubMed
Zhu, Y, Brown, HN, Zhang, Y, Stevens, RG, Zheng, TPeriod3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol Biomarkers Prev 2005; 14: 268–270.Google ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.