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Childhood trauma influences the age of onset and severity of major depressive disorder via brain function

Published online by Cambridge University Press:  13 August 2021

S. Chen  and
Y. Yuan
S. Chen*
Affiliation:
Department Of Psychosomatics And Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
Y. Yuan
Affiliation:
Department Of Psychosomatics And Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
*
*Corresponding author.

Abstract

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Introduction

Associations between childhood trauma (CT), social support (SS), brain functions and major depressive disorder (MDD) is unknown.

Objectives

This study aimed to investigate whether brain functions mediated associations between CT, SS, and MDD.

Methods

164 MDD and 98 healthy controls (HC) were recruited and measured by HAMD-24 and HAMA. Some completed CT questionnaire (CTQ) and social support rating scale (SSRS). We examined amplitude of low-frequency fluctuation (ALFF) between the two groups and correlations between HAMD-24, HAMA and ALFF in MDD. Then, the peak voxels of the ALFF changed regions were used as seeds to analyze whole-brain functional connectivity (FC). Next, correlations between FC and clinical variables of MDD were performed. Last, mediation analysis was used to further determine whether ALFF or FC could mediate the associations between CT, SS, and different clinical variables in MDD patients.

Results

Compared to HC, MDD showed decreased ALFF in right posterior cingulate (PCC_R), left postcentral gyrus, right precentral gyrus, and left thalamus (THA_L), but increased ALFF in right medial frontal gyrus, left subgenual anterior cingulate, and left middle occipital gyrus as well as decreased FC in bilateral PCC and THA_R. HAMD-24 had negative correlation with ALFF of THA_L, while positive with sexual abuse (SA) score in MDD. Mediation analysis revealed that FC of PCC_R mediated association between SA and baseline HAMD-24, and itself or together with SS mediated association between CT and onset age of MDD.

Conclusions

CT may influence the depression severity and onset age of MDD by moderating FC of PCC_R only or together with SS.

Keywords

major depressive disorderchildhood traumabrain functionsocial support
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S326
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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