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Childhood Abuse and the BDNF-Val66Met Polymorphism: Evidence for Gene-Environment Interaction in the Development of Adult Psychosis-Like Experiences

Published online by Cambridge University Press:  16 April 2020

S. Alemany ,
B. Arias ,
M. Aguilera ,
H. Villa ,
J. Moya ,
M.I. Ibañez ,
H. Vossen ,
C. Gasto ,
G. Ortet  and
L. Fañanas
S. Alemany
Affiliation:
Animal Biology, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
B. Arias
Affiliation:
Animal Biology, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
M. Aguilera
Affiliation:
Animal Biology, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
H. Villa
Affiliation:
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Facultat de Ciències Humanes i Socials, University Jaume I, Castellon, Spain
J. Moya
Affiliation:
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Facultat de Ciències Humanes i Socials, University Jaume I, Castellon, Spain
M.I. Ibañez
Affiliation:
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Facultat de Ciències Humanes i Socials, University Jaume I, Castellon, Spain
H. Vossen
Affiliation:
Animal Biology, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
C. Gasto
Affiliation:
Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Departamento de Psiquiatría, Instituto Clínico de Neurociencias, Hospital Clínico de Barcelona, Spain Instituto de Investigaciones Biomédiques August Pi i Sunyer, IDIBAPS, Barcelona, Spain
G. Ortet
Affiliation:
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Facultat de Ciències Humanes i Socials, University Jaume I, Castellon, Spain
L. Fañanas
Affiliation:
Animal Biology, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain

Abstract

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Introduction

The well-established relationship between childhood adversity and psychosis is likely to involve other factors such as genetic variants, which could help to understand why not everyone exposed to adverse events develops psychotic symptoms later in life (Van Winkel, et al. 2008; Simmons et al. 2009).

Aims

The present study investigated the influence of childhood abuse and neglect on positive and negative psychosis-like experiences in adulthood and the potential moderating effect of the BDNF-Val66Met polymorphism.

Method

Psychosis-like experiences and childhood adversity were assessed in 533 individuals from the general population.

Results

Childhood abuse showed a strong independent effect on the positive dimension of psychosis-like experiences (B = .16; SE = .05; p = .002). Furthermore, this association was moderated by the BDNF-Val66Met polymorphism (B = .17; SE = .09; p = .004).

Conclusions

Individuals exposed to childhood abuse are more likely to report positive psychosis-like experiences. Met carriers reported more positive psychosis-like experiences when exposed to childhood abuse than did individuals carrying the Val/Val genotype.

Therefore, the observed gene-environment interaction effect may be partially responsible for individual variation in response to childhood abuse.

Type
P03-212
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1381
Copyright
Copyright © European Psychiatric Association 2011
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