Professional burnout syndrome was detected among 250 persons of medical response personnel by the total examination of 900 doctors and nurses. Research provided in specific psychological areas of emergency medical response and ambulance teams affected by burning syndrome, its phenomenological mechanisms of formation are allocated. Personal related profiles, character accentuation options, emotional and motivational state of emergency medical response staff with burnout syndrome are detected. Social functioning features of emergency medical response personnel in the examined groups are researched and identified. We developed optimization for the burnout syndrome for the emergency medical response personnel based on an evaluation of its phenomenology and pathopsychological mechanisms of formation. Systematic approach used in this research allowed justifying principles of pathogenetic psychotherapeutic correction for emergency medical response staff with burnout syndrome. Approbation of the proposed correction has proved its high efficiency in 80% of personnel.