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“Bread madness” revisited: screening for specific celiac antibodies among schizophrenia patients

Published online by Cambridge University Press:  16 April 2020

Roni Peleg ,
Z. Itzhak Ben-Zion ,
Aya Peleg ,
Larisa Gheber ,
Moshe Kotler ,
Zvi Weizman ,
Asher Shiber ,
Alex Fich ,
Yael Horowitz  and
Pesach Shvartzman
Roni Peleg*
Affiliation:
Department of Family Medicine, Sial Research Center for Family Medicine and Primary Care, Division of Community Health, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Z. Itzhak Ben-Zion
Affiliation:
Department of Psychiatry, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva84105, Israel
Aya Peleg
Affiliation:
Department of Epidemiology and Department of Health Sciences Evaluation, Ben-Gurion University of the Negev, Beer-Sheva84105, Israel
Larisa Gheber
Affiliation:
Department of Gastroenterology, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva Israel, Beer-Sheva84105, Israel Department of Clinical Biochemistry, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva Israel, Beer-Sheva84105, Israel
Moshe Kotler
Affiliation:
Department of Psychiatry, Mental Health Center, Beer-Sheva84105, Israel
Zvi Weizman
Affiliation:
Department of Pediatric Gastroenterology, Division of Pediatrics, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva84105, Israel
Asher Shiber
Affiliation:
Department of Psychiatry, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva84105, Israel
Alex Fich
Affiliation:
Department of Gastroenterology, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva Israel, Beer-Sheva84105, Israel
Yael Horowitz
Affiliation:
Department of Family Medicine, Sial Research Center for Family Medicine and Primary Care, Division of Community Health, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Pesach Shvartzman
Affiliation:
Department of Family Medicine, Sial Research Center for Family Medicine and Primary Care, Division of Community Health, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
*
*Corresponding author. E-mail address: [email protected] (R. Peleg).
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Abstract

Purpose

A possible association between gluten consumption and schizophrenia has been reported. The objective was to compare patients with chronic schizophrenia and matched controls for sociodemographic variables, prevalence of celiac-specific anti-endomysial antibodies and disease-related variables.

Subjects and methods

The study group was comprised of 50 consecutive patients diagnosed with schizophrenia, 18 years of age and older attending the out-patient clinic of the Mental Health Center in Beer-Sheva, Israel. The control group was comprised of mentally normal volunteers who came to primary care clinics for blood tests unrelated to gastrointestinal tract complaints and who were not diagnosed with celiac disease. Known celiac patients and those who refused to participate, did non-speak Hebrew or were incoherent were excluded from the study. All participants in both groups underwent a blood test for anti-endomysial IgA antibody and completed a questionnaire.

Results

Each group was comprised of 50 participants. There were no significant differences between the groups in gender, BMI or country of birth. The mean age of the study group was significantly higher than the controls. All tests for anti-endomysial antibody in both groups were negative.

Discussion and conclusions

In contrast to previous reports, we found no evidence for celiac disease in patients with chronic schizophrenia as manifested by the presence of serum IgA anti-endomysial antibodies. It is unlikely that there is an association between gluten sensitivity and schizophrenia.

Keywords

CeliacSchizophreniaAnti-endomysial antibodies
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 5 , August 2004 , pp. 311 - 314
Copyright
Copyright © 2004 European Psychiatric Association

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References

De-Santis, AAddolorato, GRomito, ACaputo, SGiordano, AGambassi, Get al.Schizophrenic symptoms and SPECT abnormalities in a celiac patient: regression after a gluten free diet. J Int Med 1997;242:421–3.CrossRefGoogle Scholar
Dohan, FCCeliac disease and schizophrenia. N Engl J Med 1980;302:1262.Google Scholar
Dohan, FCCoeliac disease and schizophrenia. Lancet 1970;1:897–8.CrossRefGoogle Scholar
Dohan, FCMore on celiac disease as a model for schizophrenia. Biol Psychiatr 1983;18:561–4.Google Scholar
Editorial. Gluten in schizophrenia. Lancet 1983;1:744–5.Google Scholar
Farrell, RJKelly, CPCeliac sprue. N Engl J Med 2002;346:180–8.CrossRefGoogle ScholarPubMed
Feigheny, CCoeliac disease. BMJ 1999;319:236–9.CrossRefGoogle Scholar
Gee, SOn the coeliac disease. St Bart Hosp Rep 1888;24:17–20.Google Scholar
Gobbi, GBouquet, FGreco, LLambertini, ATassinari, CAVentura, Aet al.Coeliac disease, epilepsy and cerebral calcifications. Lancet 1992;340:439–43.Google ScholarPubMed
Hadjivassiliou, MGibson, ADavis-Jones, GALoto, AJStephenson, TJMilford-Ward, ADoes cryptic gluten sensitivity play a part in neurological illness? Lancet 1996;347:369–71.CrossRefGoogle ScholarPubMed
Hadjivassiliou, MGrunewald, RADavis-Jones, GAGluten sensitivity: a many-headed hydra. BMJ 1999;318:1710–1.CrossRefGoogle ScholarPubMed
Hallert, CPsychiatric illness, gluten and celiac disease. Biol Psychiatr 1982;17:959–61.Google ScholarPubMed
Hin, HBird, GFisher, PMahy, NJewell, DCoeliac disease in primary care: case finding study. BMJ 1999;318:164–7.CrossRefGoogle ScholarPubMed
Hockelman, RHFriedman, SBNelson, HMSeidel, HMWeitzman, MLPrimary pediatric care. 3rd ed. St. Louis: Mosby; 1997.Google Scholar
Lerner, AThe race for the diagnostic autoantibody in celiac disease. And the winner is.… IMAJ 2000;2:82–3.Google ScholarPubMed
McGuffin, PGardiner, PSwinburne, LMSchizophrenia, celiac disease and antibodies to food. Biol Psychiatr 1981;16:281–5.Google Scholar
Petitto, JMBehavioral genetics and immunity. 3rd ed. In: Ader, RFelter, LDCohen, N editors. Psychoneuroimmunology. New York: Academic Press; 2001. p. 173–86.Google Scholar
Rapaport, MHMuller, NImmunological states associated with schizophrenia. 3rd ed. In: Ader, RFelter, LDCohen, N editors. Psychoneuroimmunology. New York: Academic Press; 2001. p. 373–82.Google Scholar
Rubin, DOThe choroid plexus and system disease in mental illness. The exogenous peptide. Biol Psychiatr 1981;16:489–512.Google Scholar
Storms, LHClopton, JMWright, OEffects of gluten on schizophrenics. Arch Gen Psychiatr 1982;39:323–7.CrossRefGoogle ScholarPubMed
Scott, HBranstzaeg, PEndomysial autoantibodies. In: Peter, JBShoenfeld, Y editors. Autoantibodies. Amsterdam: Elsevier; 1996. p. 2237–44.Google Scholar
Spivak, BRadwan, MBartur, PMesteer, RWeizman, AAntinuclear autoantibodies in chronic schizophrenia. Acta Psychiatr Scand 1995; 92:266–9.CrossRefGoogle ScholarPubMed
Van Dam, P.Diagnosis and pathogenesis of CNS lupus. Rheumatology (Oxford) 1991;11:1–11.Google ScholarPubMed
Vitoria, JCArrieta, AArranz, CAyesta, ASojo, AMaruri, Net al.Antibodies to gliadin, endomysium and tissue transglutaminase for the diagnosis of celiac disease. J Pediatr Gastroenterol Nutr 1999;29:571–4.CrossRefGoogle Scholar
Wood, NCHamilton, IAxon, ATKhan, SAQuirke, PMindham, RHet al.Abnormal intestinal permeability. An aetiological factor in chronic psychiatric disorders? Br J Psychiatr 1987;150:853–6.Google ScholarPubMed
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