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Brain-derived Neurotrophic Factor (BDNF) Levels and Delirium

Published online by Cambridge University Press:  23 March 2020

D. Adamis ,
J. Williams ,
K. Finn ,
V. Melvin ,
D. Meagher  and
G. McCarthy
D. Adamis
Affiliation:
Sligo Mental Health Services, Psychiatry, Sligo, Ireland
J. Williams
Affiliation:
Sligo University Hospital, Pathology Department, Sligo, Ireland
K. Finn
Affiliation:
School of Biological Science, Cork institute of Technology, Cork, Ireland
V. Melvin
Affiliation:
Sligo Mental Health Services, Psychiatry, Sligo, Ireland
D. Meagher
Affiliation:
Graduate-Entry Medical School University of Limerick, Psychiatry, Limerick, Ireland
G. McCarthy
Affiliation:
Sligo Mental Health Services, Psychiatry, Sligo, Ireland

Abstract

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Introduction

Studies of the association between blood BDNF levels and delirium are very few and have yielded mixed results.

Objectives

To investigate the blood BDNF levels in the occurrence and recovery of delirium.

Methods

Prospective, longitudinal study. Participants were assessed twice weekly with MoCA, DRS-R98, APACHE-II. BDNF levels of the same were estimated with ELISA method. Delirium has been define as per DRS-98R (cut-off > 16) and recovery of delirium as at least two consequently assessments without delirium prior to discharge.

Results

No differences in the levels of BDNF between those with delirium and those who never developed it. Excluding those who never developed delirium (n = 140), we analysed the effects of BDNF and the other variables on delirium resolution and recovery. Of the 58 remained with delirium in the subsequently observations (max = 8) some of them continue to be delirious until discharge or death (n = 39) while others recovered (n = 19). BDNF levels and MoCA scores were significantly associated with both delirium cases who became non-delirious (resolution) during the assessments and with overall recovery. BDNF (Wald χ2 = 11.652, df: 1 P = .001), for resolution. For recovery Wald χ2 = 7.155; df: 1, P = .007. No significant association was found for the other variables (APACHE-II, history of dementia, age or gender)

Conclusions

BDNF do not have a direct effect in the occurrence of delirium but for those delirious of whom the levels are increased during the hospitalisation they are more likely to recover from delirium.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Consultation liaison psychiatry and psychosomatics–Part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s237
Copyright
Copyright © European Psychiatric Association 2017
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