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Bipolar Disorder and Parkinson disease: a 123I-FP-CIT SPECT study

Published online by Cambridge University Press:  19 July 2023

G. D’agostino ,
G. Cascino ,
A. M. Landolfi ,
R. Erro ,
P. Barone  and
P. Monteleone
G. D’agostino*
Affiliation:
Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi
G. Cascino
Affiliation:
Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi (SA)
A. M. Landolfi
Affiliation:
Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi
R. Erro
Affiliation:
Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi
P. Barone
Affiliation:
Medicine,Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Italy
P. Monteleone
Affiliation:
Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi
*
*Corresponding author.

Abstract

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Introduction

Bipolar Disorder (BD) has been suggested to be a risk factor for development of Parkinson Disease. Psychiatric drugs used as standard treatment of BD includes many drugs that are known to induce drug-induced parkinsonism (DIP).

Objectives

Clinical differentiation between PD and DIP is a clinical and scientific crucial result. It might be aided by functional neuroimaging of the dopaminergic nigrostriatal pathway.

Methods

Twenty consecutive BD patients with parkinsonism were clinically assessed and underwent 123I-ioflupane dopamine transporter SPECT. Imaging data of BD patients with pathological nigrostriatal pathway were further compared to a population of de-novo PD patients.

Results

Four BD patients had abnormal scans; they had higher putaminal binding ratio and putamen-to-caudate ratios than PD patients, despite similar motor symptom burden.

Conclusions

in our initial results, up to 20% of BD patients with parkinsonism might have an underlying dopaminergic deficit, which is higher than excepted in the general population. This evidences supports that BD represents a risk factor for subsequent development of neurodegenerative parkinsonism.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S513
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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