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Basic Symptoms in the Community and their Association with Age

Published online by Cambridge University Press:  23 March 2020

F. Schultze-Lutter ,
C. Michel ,
B.G. Schimmelmann ,
S. Ruhrmann ,
J. Kindler  and
S.J. Schmidt
F. Schultze-Lutter
Affiliation:
University of Bern, University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Bern60Switzerland
C. Michel
Affiliation:
University of Bern, University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Bern60Switzerland
B.G. Schimmelmann
Affiliation:
University of Bern, University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Bern60Switzerland
S. Ruhrmann
Affiliation:
University of Cologne, Department of Psychiatry and Psychotherapy, Cologne, Germany
J. Kindler
Affiliation:
University of Bern, University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Bern60Switzerland
S.J. Schmidt
Affiliation:
University of Bern, University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Bern60Switzerland

Abstract

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Introduction

Limited clinical relevance of attenuated psychotic symptoms before the turn from early to late adolescence, i.e., age 15/16, was reported.

Objective

This emphasizes the potentially important role of neurodevelopmental aspects in the early detection of psychoses.

Aims

We examined the age effect on prevalence and clinical relevance of 14 cognitive and perceptive basic symptoms (BS) included in risk criteria of psychosis in a random representative 8–40-year-old community sample (n = 689).

Methods

Participants underwent clinical interviews for BS, psychosocial functioning and current mental disorder on the telephone.

Results

BS were reported by 18% of participants, mainly cognitive BS (15%). Age seemed to affect perceptive and cognitive BS differently, indicating an age threshold for perceptive BS in late adolescence (around age 18) and for cognitive BS in young adulthood (early twenties) – with higher prevalence, but a lesser association with functional deficits and the presence of mental disorder in the below-threshold groups. Thereby, effects of the interaction between age and BS on functioning and mental disorder were commonly stronger than individual effects of age and BS.

Conclusion

Differential age effects of perceptual and cognitive BS seem to follow normal brain maturation processes, in which they might occur as infrequent and temporary nonpathological disturbances. Their persistence or occurrence after the conclusion of main brain maturation processes, however, might signify aberrant maturation processes. Thus, BS might provide important insight into the pathogenesis of psychosis and into potential neuroprotective targets.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Oral communications: Classification of mental disorders; comorbidity/dual pathologies; psychopathology; psychopharmacology and pharmacoeconomics and sleep disorders & stress
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S84 - S85
Copyright
Copyright © European Psychiatric Association 2017
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