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Atypical lymphocytes in schizophrenia

Published online by Cambridge University Press:  16 April 2020

RL Lahdelma ,
H Katila ,
M Hirata-Hibi ,
L Andersson ,
B Appelber  and
R Rimón
RL Lahdelma
Affiliation:
Department of Psychiatry, University of Helsinki, 00530Helsinki, Finland
H Katila
Affiliation:
Department of Psychiatry, University of Helsinki, 00530Helsinki, Finland
M Hirata-Hibi
Affiliation:
Department of Pathology, Okayama University Dental School, Okayama, Japan
L Andersson
Affiliation:
Department of Pathology, University of Helsinki, Helsinki, Finland
B Appelber
Affiliation:
Department of Psychiatry, University of Helsinki, 00530Helsinki, Finland
R Rimón
Affiliation:
Department of Psychiatry, University of Helsinki, 00530Helsinki, Finland
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Summary

Blood was drawn from 18 inpatients fullfilling the DSMIII criteria for schizophrenia and their 15 age- and sex-matched clinically infection-free controls before and after neuroleptic treatment. Blood films were stained with MGG solution, mixed, and subsequently read in random order by one observer. The lymphocytes were examined by light microscopy and classified into six types: normal lymphocytes, Downey type I atypical lymphocytes, Downey type III atypical lymphocytes, stress lymphocytes, plasmocytoid lymphocytes, and large granular lymphocytes. Downey type I and III atypical lymphocytes were classified into small, medium, and large lymphocytes. Schizophrenic patients had significantly more Downey type III medium size cells before treatment (p = 0.019 before treatment and p = 0.056 after treatment) and less Downey type I small size cells (p = 0.113 before treatment and p = 0.026 after treatment). Our study supports the idea of a possible subgroup of schizophrenia exhibiting immunological aberrations. In the present study, we found morphologically more specified cells which could be involved in this alteration.

Keywords

schizophreniaatypical lymphocytescell sizes
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 2 , 1995 , pp. 92 - 96
Copyright
Copyright © Elsevier, Paris 1995

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References

American Psychiatric Association 3rd edDSMIII: Diagnostic and Statistical Manual of Mental Disorders Washington, DC: American Psychiatric Association, 1980Google Scholar
Asberg, MMontgomery, SAPerris, CSchalling, DSedvall, GA Comprehensive Psychopathological Rating Scale. Acta Psychiatr Scand 1978; 271: 5–27CrossRefGoogle Scholar
DeLisi, LEGoodman, SNeckers, LWyatt, RJLymphocyte subpopulations in chronic schizophrenic patients. Biol Psychiatry 1982; 17: 1003–1010Google Scholar
DeLisi, LECrow, TJIs schizophrenia a viral or immunological disorder?. Psychiatr Clin North Am 1986; 9: 115–32CrossRefGoogle ScholarPubMed
Ehrnst, AWiesel, F-ABjerkenstedt, LTribukait, BJonsson, JFailure to detect immunologic stigmata in schizophrenia. Neuropsychobiology 1982; 8: 169–71CrossRefGoogle Scholar
Fessel, WJHirata-Hibi, MAbnormal lymphocytes in schizophrenia. Arch Gen Psychiatry 1963; 9: 601–13CrossRefGoogle Scholar
Fessel, WJHirata-Hibi, MShapiro, IMGenetic and stress factors affecting the abnormal lymphocyte in schizophreniaJ. Psychiatr Res 1965; 3: 275–83CrossRefGoogle Scholar
Fieve, RRBlumenthal, BLittle, BThe relationship of atypical lymphocytes, phenothiazine and schizophrenia. Arch Gen Psychiatry 1966; 15: 529–34CrossRefGoogle Scholar
Hirata-Hibi, MHigashi, STachibana, TWatanabe, NStimulated lymphocytes in schizophrenia. Arch Gen Psychiatry 1982; 39: 82–7CrossRefGoogle Scholar
Hirata-Hibi, MOh, MMiyauchi, KTachibana, TEvidence of lymphocyte abnormality in schizophreniaKurstak, ELipowski, ZJMorozov, PVViruses, Immunity, and Mental Disorders New York: Plenum, 1987; 327–40CrossRefGoogle Scholar
Hirata-Hibi, MHayashi, KThe anatomy of the P lymphocyte. Schizophr Res 1992; 8: 257–62CrossRefGoogle Scholar
Kamp, HVNuclear changes in the white blood cells of patients with schizophrenic reactions. J Neuropsychiatry 1962; 4: 1–3Google Scholar
Knight, JGDopamine-receptor-stimulating autoantibodies: a possible cause of schizophrenia. Lancet 1982; 2: 1073–1076CrossRefGoogle ScholarPubMed
Knight, JKnight, AUngvari, GCan autoimmune mechanisms account for the genetic predisposition to schizophrenia?. Br J Psychiatry 1992; 160: 533–40CrossRefGoogle Scholar
McDaniel, JSJewart, RDEccard, MBPollard, WECaudle, JStipetic, MRisby, EDLewine, RRisch, SCNatural killer cell activity in schizophrenia and schizoaffective disorder: a pilot study. Schizophr Res 1992; 8: 125–8CrossRefGoogle ScholarPubMed
Montgomery, SATaylor, PMontgomery, DDevelopment of a schizophrenia scale sensitive to change. Neuropharmacol 1987; 17: 1061–3CrossRefGoogle Scholar
Rimón, RViral aetiology in schizophrenia?. Ann Clin Res 1983; 15: 1–3Google Scholar
Torrey, FEUpshaw, YDSuddath, RMedication effect on lymphocyte morphology in schizophrenia. Schizophr Res 1989; 2: 385–90CrossRefGoogle Scholar
Vartanian, MEKolyaskina, GILozovsky, DVBurbaeva, GSAIgantov, SAAspects of humoral and cellular immunity in schizophrenia. Birth Defects Orig Artic Ser 1978; 18: 339–65Google Scholar
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