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Attenuation of learned helplessness in rats after transplant of adrenal medulla into the spinal cord

Published online by Cambridge University Press:  16 April 2020

P Tejedor-Real ,
JA Micó ,
JP Corbalan ,
I Ruz-Franzi ,
JM González-Darder  and
J Gibert-Rahola
P Tejedor-Real
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
JA Micó
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
JP Corbalan
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
I Ruz-Franzi
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
JM González-Darder
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
J Gibert-Rahola
Affiliation:
Department of Neurosciences, School of Medicine, University of Cádiz, Plaza Fragela s/n, 11003Cádiz, Spain
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Summary

The influence of an adrenal medullary transplant into the lumbar subarachnoid space on learned helplessness, an animal model of depression, was examined. The transplanted rats were found to be less susceptible than sham-operated animals to become helpless after administration of inescapable shocks. The effect was attributed to release of opioid peptides by chromaffin cells as it was reversed by naloxone. The viability of the transplanted tissue was verified by electron microscopy.

Keywords

adrenal medullary transplantopioid peptidesnaloxonelearned helplessnessdepressionrat
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 5 , 1996 , pp. 249 - 253
Copyright
Copyright © Elsevier, Paris 1996

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