To explore the relationships between Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) gene polymorphisms and schizophrenia in Chinese Han population.

The NTRK2SNPs rs1187272 were genotyped by applying polymerase chain reaction-restriction fragment length polymorphism (PCR-RLFP) technique in 100 patients with schizophrenia and 119 unrelated healthy controls, then the comparison of the alleles and genotypes frequencies of the NTRK2 gene between two groups was performed.

There were no significant difference in alleles（χ2=1.78, df=1, P>0.05）and genotypes（χ2=1.01, df=2, P>0.05） distribution of NTRK2 gene between patients and controls. There were also no significant difference in alleles（χ2=2.70, df=3, P>0.05）and genotypes（χ2=4.72, df=6, P>0.05） distribution among male and female patients and controls. There were significant difference in alleles（χ2=5.53, df=1, P=0.02）distribution between different first-onset age patients groups, There were also significant difference in alleles（χ2=4.38, df=1, P=0.04）distribution between schizophrenia with earlier first-onset age (≤25 years old) and control subjects.

The NTRK2 gene was associated with schizophrenia with earlier first-onset age, and it may be one of common susceptible genes for schizophrenia in Chinese Han population.