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Association of Adolescent Cannabis Use and Risk of Psychosis After Adjustment with Prodromal Symptoms

Published online by Cambridge University Press:  15 April 2020

A. Mustonen ,
T. Nordström ,
G.K. Murray ,
P. Mäki ,
J. Veijola ,
E. Jääskeläinen ,
S. Niemelä  and
J. Miettunen
A. Mustonen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
T. Nordström
Affiliation:
Institute of Health Sciences, University of Oulu, Oulu, Finland
G.K. Murray
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
P. Mäki
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
J. Veijola
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
E. Jääskeläinen
Affiliation:
Institute of Health Sciences, University of Oulu, Oulu, Finland
S. Niemelä
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland

Abstract

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Introduction

Recent studies have shown that cannabis use acts as a specific risk factor provoking the onset of psychosis in vulnerable individuals. Association of adolescent cannabis use and psychosis risk was studied after adjustment with prodromal symptoms.

Objectives

To assess possible causality between cannabis use and the risk of psychosis.

Aims

To examine associations between cannabis use and the risk of psychosis in 10 years follow-up while taking into account the prodromal symptoms of psychosis in a prospective general population sample.

Methods

The sample (N=6258) composed of a prospective Northern Finland Birth Cohort 1986. Questionnaire on prodromal symptoms for psychosis (PROD-screen) and on drug use was conducted when the cohort members were 15-16 years old. The participants were asked if they had tried cannabis: never, once, 2-4 times, 5 times or more. Information on psychoses was gathered from registers until age 27 years.

Results

In total 102 new psychoses emerged. The proportion of psychoses in the groups 'never”, 'once”, '2-4 times”, '5 times or more” were 1.5%, 2.8%, 3.6%, and 8.5%, respectively. The hazard ratio (HR) for risk of psychosis in subjects who had tried cannabis 5 times or more was 5.9 (95% CI 2.4-14.4) when compared to non-users. The association remained statistically significant when adjusted for prodromal symptoms and parental psychosis (HR 2.6, 1.0-6.6). When gender and smoking was taken into account association was no longer significant (HR 2.3, 0.9-6.0).

Conclusions

Adolescent cannabis use associates with increased risk of first-episode psychosis even after controlling for baseline prodromal symptoms.

Type
Article: 0381
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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