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Association between single nucleotide polymorphisms in oxytocin and vasopressin receptor genes and symptom severity of autism spectrum disorder– preliminary study

Published online by Cambridge University Press:  13 August 2021

K. Wilczyński ,
L. Cichoń ,
A. Auguściak-Duma ,
A. Sieroń  and
M. Janas-Kozik
K. Wilczyński*
Affiliation:
Department Of Psychiatry And Psychotherapy Of Developmental Age, Medical University of Silesia, Katowice, Poland Department Of Psychiatry And Psychotherapy, John Paul’s II Pediatric Center, Sosnowiec, Poland
L. Cichoń
Affiliation:
Department Of Psychiatry And Psychotherapy Of Developmental Age, Medical University of Silesia, Katowice, Poland Department Of Psychiatry And Psychotherapy, John Paul’s II Pediatric Center, Sosnowiec, Poland
A. Auguściak-Duma
Affiliation:
Department Of Molecular Biology, Medical University of Silesia, Katowice, Poland, Katowice, Poland
A. Sieroń
Affiliation:
Department Of Molecular Biology, Medical University of Silesia, Katowice, Poland, Katowice, Poland
M. Janas-Kozik
Affiliation:
Department Of Psychiatry And Psychotherapy Of Developmental Age, Medical University of Silesia, Katowice, Poland Department Of Psychiatry And Psychotherapy, John Paul’s II Pediatric Center, Sosnowiec, Poland
*
*Corresponding author.

Abstract

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Introduction

One of the defining features of autism spectrum disorder (ASD) are deficits in social interaction and communication. Although their etiology is poorly understood, several lines of evidence from studies on humans and rodents suggest that two nonapeptides – oxytocin and vasopressin – might play a pivotal role in their development.

Objectives

To evaluate if single nucleotide polimorphisms in OXTR and AVPR1A genes are linked to the severity of symptoms in autism spectrum disorder.

Methods

The study was conducted on the group of 40 Caucasian males with average age of 14,22 (SD: 1,71) years. ADOS-2 examination was utilized for confirmation of ASD diagnosis as well as evaluation of symptoms severity in each patient. The genotyping of preselected SNPs for each gene (rs10877969; rs7294536; rs2254298; rs53576) was conducted.

Results

“CC” genotype at rs7294536 (p=0,033) was significantly associated with higher outcomes of ADOS-2 especially in terms of social affect. In case of oxytocin receptor gene, frequency of “AA”/”AG” genotype at rs2254298 equaled 100% and of “AA”/”AG” genotype at rs53576 equaled 85% of the study group (expected “A” allele frequency in neurotypical European population was respectively 11% and 35% according to 1000Genomes database). For rs10877969 prevalence of “CC”/”CT” genotype equaled 95% while expected frequency of “C” allele in neurotypical European population was 13%.

Conclusions

Overrepresentation of minor alleles at rs2254298, rs53576 and rs10877969 in patients with ASD might indicate their link to development of ASD. Furthermore, significant association between minor allele at rs7294536 and symptoms severity suggest potential role of arginine-vasopressin receptor deficiency in clinical picture of ASD.

Disclosure

No significant relationships.

Keywords

oxytocinvasopressinautismsocial
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S83 - S84
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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