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Association between markers of inflammation and indicators of systemic endotoxemia in endogenous psychosis

Published online by Cambridge University Press:  01 September 2022

S. Zozulya ,
I. Oleichik ,
I. Otman ,
M. Yakovlev  and
T. Klyushnik
S. Zozulya*
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
I. Oleichik
Affiliation:
Mental Health Research Centre, Department Of Endogenous Mental Disorders And Affective Conditions, Moscow, Russian Federation
I. Otman
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
M. Yakovlev
Affiliation:
Research Institute of General Pathology and Pathophysiology, Laboratory Of Systemic Endotoxemia And Shock, Moscow, Russian Federation
T. Klyushnik
Affiliation:
Mental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The clinical and biological studies indicate the involvement of inflammation in the pathogenesis of endogenous mental disorders. The inflammation markers leukocyte elastase, α1-proteinase inhibitor, and autoantibodies to neuroantigens reflect the severity of the pathological process in the brain. Systemic endotoxemia is a pathological process caused by an excess of endotoxins in the systemic circulation, can be considered as one of the components of the inflammatory process in endogenous psychosis.

Objectives

To evaluate the association between systemic inflammation markers and indicators of systemic endotoxemia in patients with endogenous psychosis.

Methods

The study included 25 patients aged 23-49 with endogenous psychoses (F20, F25) and 25 healthy people. The severity of symptoms was assessed using PANSS. We detected the activity of leukocyte elastase and a1-proteinase inhibitor, antibodies to neuroantigens, endotoxin (ET) concentration, and antibodies to endotoxin (aEТ) in serum.

Results

In 24% of cases, an increase of inflammation markers activity, ET concentration, and aET deficiency were observed (p<0.05), which is an unfavorable factor that aggravates the clinical course of the disease. In 76% of cases, ET concentration remained within control values (p>0.05) but associated with different levels of aET, which is likely to be a consequence of previous endotoxin aggression. There were correlations between ET concentration and antibodies to neuroantigens S-100B and MBP. We also revealed the association between the activity of the inflammatory marker with the severity of clinical symptoms in patients.

Conclusions

Results suggest the relationship between systemic inflammation markers and indicators of systemic endotoxemia and their involvement in the pathogenesis of endogenous psychosis.

Disclosure

No significant relationships.

Keywords

endogenous psychosissystemic inflammationsystemic endotoxemiaantiendotoxin antibodies
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S699 - S700
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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