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Association between IL-17, IL-23 with neurocognitive scales in patients with Alzheimer’s disease

Published online by Cambridge University Press:  13 August 2021

I. Mudrenko  and
O. Chyniak
I. Mudrenko
Affiliation:
Department Of Neurosurgery And Neurology, Sumy State University, Sumy, Ukraine
O. Chyniak*
Affiliation:
Department Of Neurosurgery And Neurology, Sumy State University, Sumy, Ukraine
*
*Corresponding author.

Abstract

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Introduction

Alzheimer’s disease (AD) is a degenerative brain disease and the most common cause of dementia. Evidence suggests that various cytokines, including interleukins (IL) IL-6, IL-10, IL-12 are actively involved in the pathogenesis of AD. The role of IL-17 and IL-23 is less clear.

Objectives

To investigate the correlations between IL-17, IL-23, and neurocognitive scales in patients with Alzheimer’s disease.

Methods

The study included 45 patients: 15 patients with Alzheimer’s disease and 30 patients without cognitive deficit (control group). Clinical and psychometrical methods were used: Mini Mental State Examination (MMSE) scale; Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Alzheimer Disease Assessment Scale-cognitive (ADAS ̶ cog). Serum levels of cytokines of IL-17 and IL-23 were analyzed by sandwich ELISA on “Chem Well 2900” immunoanalyzer (Awareness Technology, USA).

Results

A significantly positive correlation was observed between IL-17 and IL-23 for all AD patients (r =0.723, p=0.002). A significant inverse correlation was observed between serum concentration of IL-17 and MoCA score (r=˗1.0, р≤.0001) and IL-23 and MMSE score (r=˗0.553, р=0.032) in all AD patients. However, no other significant correlations were found between IL-17 and the scores MMSE, FAB, ADAS ̶ cog and between IL-23 and the scores MoCA, FAB and ADAS ̶ cog.

Conclusions

Proinflammatory cytokines (such as IL-17 and IL-23) have been associated with cognitive impairment. However, the complicated relationships of the two cytokines with the pathogenesis of AD need to be further investigated in the future.

Disclosure

No significant relationships.

Keywords

Alzheimer’s diseaseinflammationinterleukinneurocognitive scales.
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S718 - S719
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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