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The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study

Published online by Cambridge University Press:  19 July 2023

G. Erzin ,
C. Atbaşoğlu ,
L. Fusar-Poli ,
M. C. Saka ,
A. Üçok ,
K. Alptekin ,
J. V. Os ,
G. Gümüş Akay  and
S. Gülöksüz
G. Erzin*
Affiliation:
1Ankara Diskapi Training and Research Hospital
C. Atbaşoğlu
Affiliation:
2Ankara University, Medical Faculty, Psychiatry Department, ankara, Türkiye
L. Fusar-Poli
Affiliation:
3University of Catania, Medical Faculty, Psychiatry Department, Catania, Italy
M. C. Saka
Affiliation:
2Ankara University, Medical Faculty, Psychiatry Department, ankara, Türkiye
A. Üçok
Affiliation:
4İstanbul University, Medical Faculty, Psychiatry Department, İstanbul
K. Alptekin
Affiliation:
5Dokuzeylül University, Medical Faculty, Psychiatry Department, İzmir, Türkiye
J. V. Os
Affiliation:
6Utrecht University, Medical Center, Psychiatry Department, Utrecht, Netherlands
G. Gümüş Akay
Affiliation:
7Ankara University, Medical Faculty, Physiology Department, Ankara, Türkiye
S. Gülöksüz
Affiliation:
8Maastricht University, Psychiatry and Neuropsychology Department, Maastricht, Netherlands
*
*Corresponding author.

Abstract

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Introduction

Exposome is all nongenetic exposures from the prenatal period to death. Exposome score for schizophrenia (ES-SCZ) is a cumulative measure of environmental liability for schizophrenia. Our previous studies showed that the ES-SCZ is associated with mental and physical health outcome.

Objectives

The aim of the study is to investigate the association of the ES-SCZ with metabolic parameters in individuals with schizophrenia and healthy controls.

Methods

This study obtained 124 individuals with schizophrenia and 440 healthy controls from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions, Work Package 6 (Vulnerability and Severity) Turkey dataset. The ES-SCZ was calculated by summing log-odds weighted environmental exposures (childhood adversities, winter birth, hearing impairment and cannabis use). Linear regression analysis was used to investigate the association between ES-SCZ and metabolic parameters. After that analysis age and sex were added as covariates.

Results

There was an association between ES-SCZ and diastolic blood pressure (B = -2.69 [95% CI -4.74; -.65], P-value = 0.010) in schizophrenia. ES-SCZ was associated with the fasting glucose level (B = -6.23 [95% CI -11.59; -.87], P-value = 0.023); high density lipid level (B = 1.77 [95% CI .27; 3.27], P-value = 0.021) in control and these results remained significant after adjusting for age and sex.

Conclusions

ES-SCZ was associated with important metabolic parameters. These findings show that ES-SCZ is not only related to increasing the risk for psychosis development but may also influence comorbidities. This result is important since it may increase our knowledge of ES-SCZ and contribute to the importance and framework of its clinical implementation.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S264
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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