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Association between cingulum bundle structure and cognitive performance: An observational study in major depression

Published online by Cambridge University Press:  16 April 2020

I. Schermuly ,
A. Fellgiebel ,
S. Wagner ,
I. Yakushev ,
P. Stoeter ,
R. Schmitt ,
R.J. Knickenberg ,
F. Bleichner  and
M.E. Beutel
I. Schermuly*
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
A. Fellgiebel
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
S. Wagner
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
I. Yakushev
Affiliation:
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
P. Stoeter
Affiliation:
Institute of Neuroradiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
R. Schmitt
Affiliation:
Clinic for Radiology, Rhoen Klinikum, Bad Neustadt an der Saale, Germany
R.J. Knickenberg
Affiliation:
Psychosomatic Clinic, Rhoen Klinikum, Bad Neustadt an der Saale, Germany
F. Bleichner
Affiliation:
Psychosomatic Clinic, Rhoen Klinikum, Bad Neustadt an der Saale, Germany
M.E. Beutel
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
*
*Corresponding author. Tel.: +49 0 6131 172488; fax: +49 0 6131 176690. E-mail address: [email protected] (I. Schermuly).
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Abstract

Background

Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression.

Methods

Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression.

Results

FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory.

Conclusions

Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.

Keywords

Diffusion-tensor imagingDTICingulum bundleDepressionExecutive function
Type
Brain Anatomy and Imaging
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 355 - 360
Copyright
Copyright © Elsevier Masson SAS 2010

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