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Apolipoprotein E-ε4 frequency in deficit schizophrenia

Published online by Cambridge University Press:  16 April 2020

F Thibaut ,
A Van der Elst ,
D Campion ,
C Martin ,
B Coron ,
S Dollfus ,
TH Frebourg  and
M Petit
F Thibaut
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
A Van der Elst
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
D Campion
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
C Martin
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
B Coron
Affiliation:
Research Group, Psychopathology and Schizophrenias (JE 2014), University of Medicine at Rouen and Caen, Rouen, France
S Dollfus
Affiliation:
Research Group, Psychopathology and Schizophrenias (JE 2014), University of Medicine at Rouen and Caen, Rouen, France
TH Frebourg
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
M Petit
Affiliation:
Molecular Genetic Unit (Unité INSERM EPI 9906), IFR 23, CHU de Rouen
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Summary

The apolipoprotein E (ApoE) genotype has been found to affect the expression of several neuropsychiatric disorders. We determined ApoE genotype frequencies and their relationship to primary negative symptoms in 61 non-deficit and 45 deficit schizophrenic patients, and compared them with 98 control subjects. No difference was observed when genotype or allele frequencies were compared between the three groups. Our data do not support a role for ApoE in the phenotypic expression of schizophrenia.

Keywords

apolipoprotein Edeficit syndromeschizophrenia
Type
Original Articles
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 148 - 151
Copyright
Copyright © European Psychiatric Association 1999

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