Research goal of our study is to confirm the value of Cognitive- behavioral therapy (CBT) in patients with anxiety disorder. We compared a group of 20 patients age 37.15±10.4 (65% were women) treated only with antidepressive and anxiolitic medications, with other group of 20 patients age 37.5±10.4 (70% women) treated with psychopharmacotherapy and cognitive - behavioral therapy. For one year there have been used Beck Anxiety Inventory (BAI) on the beginning and at the end of treatment. Before the treatment most of the patients (13) in the group treated with drugs only expressed moderate anxiety (17-29 according the BAI), and after the treatment expressed minimal anxiety (0-9 according the BAI). Those patients treated with drugs and cognitive behavioral therapy showed 17 patients with severe anxiety before treatment, and 20 patients showed minimal anxiety after treatment. The group of patients treated with drugs only exposed significantly a lower levels of anxiety (p=0.0001) in comparison with the group treated with drugs and CBT. Mean value of BAI in the group treated only with pharmacotherapy at the beginning of treatment was 24.95±8.2 and at the end 7.5±4.3, with an average benefit of 17.4±8.2. In the group of patients treated also with cognitive-behavioral therapy at the beginning was 35.6±10.7 and at the end 3±1.5, with average improvement of 32.6±10.1. That is significantly higher than in first group (p<0.0001).