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Anti-correlated Brain Networks and Self-agency Experience in First-episode Schizophrenia-spectrum Patients. an FMRI Study.

Published online by Cambridge University Press:  15 April 2020

F. Spaniel ,
J. Tintera ,
J. Rydlo ,
I. Ibrahim ,
J. Horacek ,
T. Kasparek  and
C. Höschl
F. Spaniel
Affiliation:
Psychiatry, Prague Psychiatric Centre, Prague, Czech Republic
J. Tintera
Affiliation:
MRI unit, Institute for Clinical and Experimental Medicine MR-Unit ZRIR, Prague, Czech Republic
J. Rydlo
Affiliation:
MRI unit, Institute for Clinical and Experimental Medicine MR-Unit ZRIR, Prague, Czech Republic
I. Ibrahim
Affiliation:
MRI unit, Institute for Clinical and Experimental Medicine MR-Unit ZRIR, Prague, Czech Republic
J. Horacek
Affiliation:
Psychiatry, Prague Psychiatric Centre, Prague, Czech Republic
T. Kasparek
Affiliation:
Psychiatry, Department of Psychiatry University Hospital Brno Faculty of Medicine Masaryk University Brno Czech Republic, Prague, Czech Republic
C. Höschl
Affiliation:
Psychiatry, Prague Psychiatric Centre, Prague, Czech Republic

Abstract

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Abstract

In this study we sought to explore patterns of neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia spectrum disorders (FES) and healthy controls (HC).

Participants

Thirty-five FES patients and 35 age-, gender- and education-matched healthy controls.

Main Outcome Measures

A task-related functional connectivity analysis with the use of independent component analysis (ICA).

Results

ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task.

Time-courses of DMN/CEN activity has been analyzed by means of signal power and spectral coherence. There was statistically significant difference in the variable (anti-correlation index, AI) between FES and HC. AI correlated with self-agency judgment task performance in FES.

Conclusions

This finding suggests that the main site of pathology in schizophrenia-spectrum disorders may originate in higher-order regulatory mechanisms subserving DMN/CEN orchestration.

Funding/Support

The study was supported by the IGA Ministry of Health, Czech Republic, grant NT/14291.

Type
Article: 0897
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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