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Anti NMDAR encephalitis masked by symptoms of postpartum depression

Published online by Cambridge University Press:  19 July 2023

S. Milanovic Hromin*
Affiliation:
GENERAL HOSPITAL ZADAR, Zadar
A. Jelcic
Affiliation:
Ginekologija Dana d.o.o. for gynecology, obstetrics and consulting, Zagreb
R. Perincic
Affiliation:
Private psychiatric office dr Robert Perincic, Zadar
M. Komso
Affiliation:
GENERAL HOSPITAL ZADAR, Zadar
B. Barun
Affiliation:
Department for neuroimunology of CNS, Clinical hospital center Zagreb
M. Grah
Affiliation:
Clinic for psychiatry Sveti Ivan, Zagreb, Croatia
S. Zecevic Penic
Affiliation:
Neurological outpatient clinic, Clinic for psychiatry Sveti Ivan, Zagreb
S. Biloglav
Affiliation:
Department for psychiatry, GENERAL HOSPITAL ZADAR, Zadar, Croatia
I. Perincic
Affiliation:
Department for psychiatry, GENERAL HOSPITAL ZADAR, Zadar, Croatia
M. Juresko
Affiliation:
Department for psychiatry, GENERAL HOSPITAL ZADAR, Zadar, Croatia
B. Skific
Affiliation:
Department for psychiatry, GENERAL HOSPITAL ZADAR, Zadar, Croatia
*
*Corresponding author.

Abstract

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Introduction

Anti NMDAR encephalitis is a relatively common autoimmune encephalitis characterized by complex neuropsychiatric features and the presence of Immunoglobulin G antibodies against the NR1 subunit of the NMDA receptors in the central nervous system. It causes psychiatric features, confusion, memory loss and seizures followed by a movement disorder, loss of consciousness and changes in blood pressure, heart rate and temperature. Postpartum depression symptoms usually develop within the first few weeks after giving birth , but may begin earlier/during pregnancy / or later /up to a year after birth. They include: inability to sleep or sleeping too much, depressed mood or severe mood swing, difficulty bonding with your baby, withdrawing from family and friends, fatigue or loss of energy, feelings of shame, guilt or inadequacy, diminished ability to think clearly, concentrate or make decisions, anxiety and panic attacks, thoughts of harming yourself or your baby. Untreated may last for many months or longer.

Objectives

Recent studies have highlighted the possibility that a subset of patients with first-onset severe psychiatric episodes might suffer from undiagnosed autoimmune encephalitis. The acute onset of severe atypical psychiatric symptoms in young female patients should raise the index of suspicion for anti-NMDA receptor encephalitis, particularly in the setting of neurological symptoms, including side effects of antipsychotic treatment.

Methods

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Results

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Conclusions

Creating a therapeutic environment is an interdisciplinary clinical and theoretical approach to psychiatric treatment in hospital settings, the basic idea of which is that the entire environment has therapeutic potential. Psychodinamic knowledge and understanding of the process as well as principles of body-oriented psychotherapy may be of great importance in the treatment of these patients in addition to the use of pharmacotherapy.

Disclosure of Interest

None Declared

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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