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Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

Published online by Cambridge University Press:  16 April 2020

Tanja M. Michel ,
Sophia Frangou ,
Sibylle Camara ,
Dorothea Thiemeyer ,
Julia Jecel ,
Thomas Tatschner ,
Robert Zoechling  and
Edna Grünblatt
Tanja M. Michel*
Affiliation:
RWTH Aachen University, Department of Psychiatry and Psychotherapy, Pauwelsstrasse 30, 52074Aachen, Germany Section of Neurobiology of Psychosis, PO 66, NIHR Biomedical Research Centre and Institute of Psychiatry, Kings College London, De Crespigny Park, SE5 8AF, London, UK Deptartment of Psychiatry and Psychotherapy, University Hospital Würzburg Füchsleinstrasse 15, 97080Würzburg, Germany
Sophia Frangou
Affiliation:
Section of Neurobiology of Psychosis, PO 66, NIHR Biomedical Research Centre and Institute of Psychiatry, Kings College London, De Crespigny Park, SE5 8AF, London, UK
Sibylle Camara
Affiliation:
Deptartment of Psychiatry and Psychotherapy, University Hospital Würzburg Füchsleinstrasse 15, 97080Würzburg, Germany
Dorothea Thiemeyer
Affiliation:
Deptartment of Psychiatry and Psychotherapy, University Hospital Würzburg Füchsleinstrasse 15, 97080Würzburg, Germany
Julia Jecel
Affiliation:
Insitute for Forensic Medicine, University Würzburg, Germany
Thomas Tatschner
Affiliation:
Department of Psychiatry, Hospital Mostviertel Amstetten-Mauer, Austria
Robert Zoechling
Affiliation:
Department of Neurology, Danube-Hospital Vienna, Austria
Edna Grünblatt
Affiliation:
Deptartment of Psychiatry and Psychotherapy, University Hospital Würzburg Füchsleinstrasse 15, 97080Würzburg, Germany
*
*Corresponding author. RWTH Aachen University, Department of Psychiatry and Psychotherapy, Pauwelsstrasse 30, 52074 Aachen, Germany Tel.: +49 241 808 9506. E-mail address: [email protected] (T.M. Michel).
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Abstract

Introduction

A growing body of evidence suggests that the glial cell line-derived neurotrophic factor (GDNF) is involved in the aetiopathology of mood disorders. GDNF is a neurotrophic factor from the transforming growth factor-β-family, playing a role in cell development and function in the limbic system. This is the first study to examine GDNF concentration in different brain regions of patients with depressive disorder (DD).

Material and Methods

We used sandwich-ELISA-technique to ascertain GDNF concentration and Lowry assay for overall protein levels in post-mortem brain tissue of 7 patients with recurrent depressive disorder and 14 individuals without any neurological or psychiatric diagnoses. We included cortical regions as well as limbic area's (hippocampus, entorhinal cortex) basal ganglia (putamen, caudate nucleus), thalamus and cingulated gyrus.

Results

We found a significant increase in GDNF concentration in the parietal cortex of patients with DD compared to the control group. In other regions the trend of an increased GDNF concentration did not reach statistical difference.

Discussion

This proof of concept study supports previous findings of an alteration of the GDNF in patients with depressive disorder. However, for the first time a significant increase of GDNF in a cortical brain area was found in DD.

Keywords

Psychiatric disorderAffective disordersNeuroscience otherMiscellaneousAntidepressantGDNF
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 6 , September 2008 , pp. 413 - 420
Copyright
Copyright © Elsevier Masson SAS 2008

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