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Altered Executive Function in Suicide Attempts

Published online by Cambridge University Press:  01 September 2022

J. Fernández*
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA. Universidad del País Vasco, Departamento de Neurociencias, Psychiatry, Vitoria-Gasteiz , Spain
S. Alberich
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA, Psychiatry, Vitoria-Gasteiz , Spain
I. Zorrilla
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA. Universidad del País Vasco, Departamento de Neurociencias, Psychiatry, Vitoria-Gasteiz , Spain
I. González-Ortega
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA, Psychiatry, Vitoria-Gasteiz , Spain
M.P. López
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA. Universidad del País Vasco, Departamento de Neurociencias, Psychiatry, Vitoria-Gasteiz , Spain
V. Pérez-Solà
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
E. Vieta
Affiliation:
Hospital Clínic de Barcelona, Bipolar And Depressive Disorders Unit, Institute Of Neuroscience, Barcelona, Spain
A.M. González-Pinto
Affiliation:
Asociación Instituto de Investigación Sanitaria BIOARABA. Universidad del País Vasco, Departamento de Neurociencias, Psychiatry, Vitoria-Gasteiz , Spain
P.A. Saiz
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
*
*Corresponding author.

Abstract

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Introduction

Executive function organizes and directs behaviour but alterations in this cognitive domain can lead to inaccurate perception, interpretation and response to environmental information, which could be a risk factor for suicide.

Objectives

To explore executive function performance of depressed recent suicide attempters in comparison to depressed past suicide attempters, depressed non-attempters and healthy controls.

Methods

96 participants from the Psychiatry Department of the Araba University Hospital-Santiago were recruited as follows: 20 patients with a recent suicide attempt (<30days) diagnosed with a Major Depressive Disorder (MDD), 33 MDD patients with history of attempted suicide, 23 non-attempter MDD patients and 20 healthy controls. All participants underwent a clinical interview and neuropsychological assessment on executive function with the Wisconsin Sorting Card Test. Backward multiple regressions were performed adjusting for significant confounding variables. For group comparisons ANOVA test and Bonferroni post hoc test were performed with p<0.05 significance level.

Results

Patient groups did not differ regarding severity of depression. All patient groups performed significantly worse than healthy controls on executive function. Adjusted comparisons between patient groups indicated that recent suicide attempters had a poorer performance in this cognitive domain in comparison to both depressed lifetime attempters and depressed non-attempters (B=0.296, p=0.019 and B=0.301, p=0.028 respectively).

Conclusions

Executive function performance is altered in recent suicide attempts. As impaired executive function can be a risk factor for suicide, preventive interventions on suicide should focus on its assessment and rehabilitation.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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