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Allelic association between dinucleotide repeats at the monoamine oxidase loci and schizophrenia

Published online by Cambridge University Press:  16 April 2020

J Wei  and
GP Hammings
J Wei
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, GwyneddLL.57 2AG, UK
GP Hammings
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, GwyneddLL.57 2AG, UK
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Summary

Two X-linked microsatellites, (AC)n repeats at the monoamine oxidase (MAO) A locus and (TG)n repeats at the MAO-B locus, were typed by using a PCR-based procedure in 89 nuclear families consisting of mothers, fathers and female affected offspring with schizophrenia or mothers and male affected offspring. A haplotype-based haplotype relative risk (HHRR) approach was applied to detect allelic association of these two microsatellites with schizophrenia. In the families of male patients, a significant difference in frequency distribution was found between transmitted and non-transmitted (TG)n repeats (χ2 = 15.13, df = 6, P = 0.019), and Fisher's exact test showed that allelic frequency of the transmitted (TG)24 was significantly higher than that of the non-transmitted (TG)24 (Fisher's P = 0.003). However, no significant differences in frequency distribution between mother- or father-transmitted and non-transmitted (TG)n repeats were found in the families of female patients. No significant differences in frequency distribution were found between transmitted and non-transmitted (AC)n repeats in the families of either male patients or female patients. The present study suggests that the MAO-B gene may be associated with schizophrenia, and the underlying genetic mechanism of schizophrenia may differ between male and female schizophrenic individuals.

Keywords

monoamine oxidasegenemicrosatellitepolymerase chain reaction (PCR)schizophrenia
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue 8 , December 1998 , pp. 407 - 410
Copyright
Copyright © Elsevier, Paris 1998

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