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Alcohol Use Disorder and Depression: The Complexity of Comorbidity

Published online by Cambridge University Press:  27 August 2024

A. H. I. Abu Shehab ,
T. Simona ,
A. B. Ciubară ,
D. C. Voinescu ,
L. Burlea  and
A. Ciubară
A. H. I. Abu Shehab*
Affiliation:
1Psychiatry Department, “Elisabeta Doamna” Psychiatric Hospital, Galati
T. Simona
Affiliation:
2Psychiatry Department, Carol Davila University of Medicine and Pharmacy, Bucharest
A. B. Ciubară
Affiliation:
3Orthopedics and traumatology Department
D. C. Voinescu
Affiliation:
4Rheumatology department, “Dunărea de Jos” University - Faculty of Medicine and Pharmacy, Galati
L. Burlea
Affiliation:
5Technology, Prothesis and Implantology, University of Medicine and Pharmacy “Grigore T. Popa”, Iași
A. Ciubară
Affiliation:
6Psychiatry Department, “Dunărea de Jos” University - Faculty of Medicine and Pharmacy, Galati, Romania
*
*Corresponding author.

Abstract

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Introduction

Alcohol Use Disorder (AUD) and depression are among the most prevalent mental health concerns on a global scale. The co-occurrence of alcohol use disorder (AUD) and depression has been well acknowledged, leading to intricate issues in diagnosis, treatment, and prognosis.

Objectives

This study aims to analyse the complex correlation between AUD (Alcohol Use Disorder) and depression, with a specific emphasis on examining common underlying causes, reciprocal influences, and potential implications for clinical treatment.

Methods

An exhaustive review of literature was undertaken, emphasizing epidemiological studies, neurobiological research, and the efficacy of combined treatment modalities. The review also delved into the potential role of genetics, environmental factors, and psychosocial stressors in co-occurrence.

Results

The available evidence indicates that there exists a reciprocal relationship between depression and alcohol use disorder (AUD), wherein each disease can serve as a triggering factor for the other. This interplay between depression and AUD forms a detrimental cycle that intensifies the severity of both conditions. The comorbidity of various disorders may be attributed to the presence of shared neurochemical pathways, with a particular emphasis on the serotonin system. Furthermore, the co-occurrence of both illnesses frequently leads to heightened symptom severity, reduced treatment efficacy, and a higher risk of suicide.

Conclusions

The complex relationship between alcohol use disorder (AUD) and depression underscores the need for a comprehensive and integrated therapy strategy. The effective management of this comorbidity necessitates the implementation of multidisciplinary collaboration, patient education, and early intervention.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S528 - S529
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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