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Adjunctive gabapentin treatment of bipolar disorder

Published online by Cambridge University Press:  16 April 2020

E Vieta ,
A Martinez-Arán ,
E Nieto ,
F Colom ,
M Reinares ,
A Benabarre  and
C Gastó
E Vieta*
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
A Martinez-Arán
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
E Nieto
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
F Colom
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
M Reinares
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
A Benabarre
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
C Gastó
Affiliation:
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
*
*Correspondence and reprints: Dr. E. Vieta. Clinical Institute of Psychiatry and Psychology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
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Abstract

Introduction

The aim of this study was to analyze the effectiveness of gabapentin administration to bipolar patients who had an incomplete response to other mood stabilizers.

Subjects and methods

Twenty-two RDC bipolar 1 and II patients were assessed by means of the SADS and entered if they gave their consent to participate. All them had suffered from frequent relapses, subsyndromal features (mostly depressive) and incomplete response to other drugs. They all received open-label increasing doses of gabapentin until clinical response. The patients were assessed through the CGI-BP and a specific questionnaire at baseline and at 12 weeks of follow-up.

Results

Six out of the 22 patients dropped out for various reasons (four because of relapse, one because of side effects and one more because of poor compliance). Eight of the 16 patients that completed the 12-week follow-up showed at least two stages of improvement in the CGI. Using the last observation-carried forward analysis, the improvement was statistically significant for the depression subscale, and apparently related to social functioning, irritability and anxiety. Only one patient dropped out because of intolerance (mild rash). The mean dose of gabapentin was 1,310 mg/day.

Conclusion

Gabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. These results should be confirmed in randomized clinical trials.

Keywords

bipolar disordergabapentinopen-label study
Type
Original article
Information
European Psychiatry , Volume 15 , Issue 7 , November 2000 , pp. 433 - 437
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

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References

AItshuler, LLKeck, P.E JrMcElroy, SLSuppes, TBrown, ESDenicoff, K et al. Gabapentin in the acute treatment of refractory bipolar disorder Bipolar Disord 1999; 1: 61–65CrossRefGoogle Scholar
Cabras, PLHardoy, JHardoy, MCCarta, MGClinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study J Clin Psychiatry 1999; 60: 245–248CrossRefGoogle ScholarPubMed
Dichter, MABrodie, MINew antiepileptic drugs New Engl J M 1996; 334: 1583–1590CrossRefGoogle ScholarPubMed
Erfiifth, AKammerer, CGrunze, HNormann, CWalden, JAn open label study of gabapentin in the treatment of acute mania J Psychiatr Res 1998; 32: 261–264Google Scholar
Freeman, WStoll, ALMood stabilizer combinations: a review of safety and efficacy Am J Psychiatry 1998; 155: 12–21CrossRefGoogle ScholarPubMed
Frye, MA, Ketter, TA, Osuch, ED, Krimbell, TA, Post, RM. Gabapentin and lamotrigine monotherapy in mood disorders. Presented at the 1998 Annual Meeting of the American Psychiatric Association. Abstract 77D, p. 150Google Scholar
Ghaemi, SNSachs, GSLong-term risperidone treatment in bipolar disorder: 6-month follow-up Int Clin Psychopharmacology 1997; 12: 333–338CrossRefGoogle ScholarPubMed
Ghaemi, SNKatzow, JJDesai, SPGoodwin, FKGabapentin treatrnent of mood disorders: a preliminary study J Clin Psychiatry 1998; 59: 426–429CrossRefGoogle Scholar
Keck, PEMcElroy, SLStrakowski, SMAnticonvulsants and antipsychotics in the treatment of bipolar disorder J Clin Psychiatry 59 Suppl 6 1998 74–81Google ScholarPubMed
Knoll, JStegman, KSuppes, TClinical experience using gabapentin adjunctively in patients with a history of mania or hypomania J Affect Disord 1998; 49: 229–233CrossRefGoogle ScholarPubMed
McElroy, SLSoutullo, CAKeck, P.E JrKmetz, GRA pilot trial of adjunctive gabapentin in the treatment of bipolar disorder Ann Clin Psychiatry 1997; 9: 99–103CrossRefGoogle ScholarPubMed
Pande, ACCombination treatment in bipolar disorder Bipolar Disord 1 Suppl 1 1999 17–17Google Scholar
Pande, ACDavidson, J.R.TJefferson, JWJanney, CAKatzelnick, DJWeisler, RH et al. Treatment of social phobia. with gabapentin: a placebo-controlled study J Clin Psychopharmacol 1999; 19: 341–348CrossRefGoogle ScholarPubMed
Pollack, MHMatthews, JScott, ELGabapentin as a potential treatment for anxiety disorders Am J Psychiatry 1998; 155: 992–993CrossRefGoogle ScholarPubMed
Post, RMFrye, MALeverich, GSDenicoff, KDThe role of complex combination therapy in the treatment of refractory bipolar illness CNS Spectrums 1998; 3: 66–86CrossRefGoogle Scholar
Sanger, TM, Tohen, M, Jacobs, T, Gannon, KS, Greaney, M, Tollefson, GD. Long-term olanzapine treatment of mania. New Research Program and Abstracts of the 1999 Annual Meeting of the American Psychiatric Association 1999: 190Google Scholar
Schaffer, CBSchaffer, LCGabapentin in the treatment of bipolar disorder Am J Psychiatry 1997; 154: 291–292Google ScholarPubMed
Spearing, MKPost, RMLeverich, GSBrandt, DNolen, WModification of the Clinical Global Impressions (CGI) Scale for use in bipolar illness (BP): the CGI-BP Psychiatry Res 1997; 73: 159–171CrossRefGoogle ScholarPubMed
Stanton, SPKeck, P.E JrMcElroy, SLTreatment of acute mania with gabapentin Am J Psychiatry 1997; 154: 287Google ScholarPubMed
Vieta, EDiagnosis and classification of psychiatric disordersSussman, NAnticonvulsants in psychiatry. Round table series n° 64 1999 The Royal Society of Medicine Press London3–8Google Scholar
Vieta, EGastó, CColom, FMartínez, AOtero, AVallejo, JTreatment of refractory rapid cycling bipolar disorder with risperidone J Clin Psychopharmacol 1998; 18: 172–174CrossRefGoogle ScholarPubMed
Young, LTCooke, RGRoob, JCLevitt, AJJoffe, RTAnxious and non-anxious bipolar disorder J Affect Disord 1993; 29: 49–52CrossRefGoogle ScholarPubMed
Young, LTRobb, JCPatelis-Siotis, IMacDonald, CJoffe, RTAcute treatment of bipolar depression with gabapentin Biol Psychiatry 1997; 42: 851–853CrossRefGoogle ScholarPubMed
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