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Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial

Published online by Cambridge University Press:  15 April 2020

G. Scantamburlo ,
M. Hansenne ,
V. Geenen ,
J.J. Legros  and
M. Ansseau
G. Scantamburlo*
Affiliation:
Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium
M. Hansenne
Affiliation:
Department of Cognitive Sciences, Faculty of Psychology, University of Liège, Liège, Belgium
V. Geenen
Affiliation:
Immunoendocrinology Center, GIGA3, University of Liège, Liège, Belgium
J.J. Legros
Affiliation:
Departement of Endocrinology, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium
M. Ansseau
Affiliation:
Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium
*
*Corresponding author. Tel.: +32 4 366 79 60. E-mail address:[email protected] (G. Scantamburlo).
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Abstract

The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded to 40 mg of escitalopram, received intranasal synthetic oxytocin during 4 weeks, in association with antidepressant. This is the first open trial study suggesting OT in association with escitalopram significantly reduced scores on Hamilton Depression Rating Scale.

Keywords

Major depressionIntranasal oxytocinAnxiety
Type
Short communication
Information
European Psychiatry , Volume 30 , Issue 1 , January 2015 , pp. 65 - 68
Copyright
Copyright © Elsevier Masson SAS 2015

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