Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-20T00:18:11.318Z Has data issue: false hasContentIssue false
  • English
  • Français

Verbal fluency as a possible predictor for psychosis

Published online by Cambridge University Press:  16 April 2020

H.E. Becker ,
D.H. Nieman ,
P.M. Dingemans ,
J.R. van de Fliert ,
L. De Haan  and
D.H. Linszen
H.E. Becker*
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
D.H. Nieman
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
P.M. Dingemans
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
J.R. van de Fliert
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
L. De Haan
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
D.H. Linszen
Affiliation:
Department of Psychiatry, Academic Medical Centre, Meibergdreef 5, 1105 AZAmsterdam, Netherlands
*
*Corresponding author: Tel.: +31 20 8913570; fax: +31 20 8913536. E-mail address: [email protected] (H.E. Becker).
Get access

Abstract

Background

Neurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients.

Aim

To compare verbal fluency performance at baseline in UHR in patients that did and did not make the transition to psychosis.

Method

Baseline verbal fluency performance in UHR-patients (n = 47) was compared to match first episode patients (n = 69) and normal controls (n = 42).

Results

Verbal fluency (semantic category) scores in UHR-patients did not differ significantly from the score in first episode schizophrenia patients. Both the UHR group (p < 0.003) and the patient group (p < 0.0001) performed significantly worse than controls. Compared to the non-transition group, the transition group performed worse on verbal fluency, semantic category (p < 0.006) at baseline.

Conclusions

Verbal fluency (semantic category) is disturbed in UHR-patients that make the transition to psychosis and could contribute to an improved prediction of transition to psychosis in UHR-patients.

Keywords

Schizophrenia and psychosisUltra high riskNeuropsychologyTransition to psychosis
Type
Original articles
Information
European Psychiatry , Volume 25 , Issue 2 , March 2010 , pp. 105 - 110
Copyright
Copyright © Elsevier Masson SAS 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albus, M., Mohr, F., Hecht, S., Hinterberger-Weber, P., Seitz, N.N., Küchenhoff, H.Neurocognitive functioning in patients with first episode schizophrenia: results of a prospective 5-year follow-up study. Eur Arch Psychiat Clin Neurosci. 2006; 256(7): 442–451.CrossRefGoogle ScholarPubMed
Andrews, G., Peters, L.The psychometric properties of the Composite International Diagnostic Interview. Soc Psychiatr Epidemiol 1998; 33: 80–88.CrossRefGoogle ScholarPubMed
Brewer, W., Francey, S., Wood, S., Jackson, H., Pantelis, C., Philips, L.et al. Memory impairments identified in people at ultra high risk for psychosis who later develop first episode psychosis. Am J Psychiat 2005; 162: 71–78.CrossRefGoogle ScholarPubMed
Byrne, M., Clafferty, R., Cosway, R., Grant, E., Hodges, A., Whalley, H.C.et al. Neuropsychology, genetic liability and psychosis in those at high risk for schizophrenia. J Abnormal Psychol 2002; 160: 2060–2062.Google Scholar
Cornblatt, B., Lencz, T., Smith, C., Correll, C., Auther, A., Nakayama, E.The schizophrenia prodrome revisited: a neuro-developmental perspective. Schizophr Bull. 2003; 29(4): 633–651.CrossRefGoogle Scholar
Cosway, R., Byrne, M., Clafferty, R., Hodges, A., Grant, E., Morris, J.et al. Sustained attention in young people at high risk for schizophrenia. Psychol Med 2002; 32: 277–286.CrossRefGoogle ScholarPubMed
Eastvold, A., Heaton, R., Cadanhead, K.Neurocognitive deficits in the (putative) prodromal and first episode of psychosis. Schizophr Res 2007; 93: 266–277.CrossRefGoogle Scholar
Ehlis, A., Herrmann, A., Plichta, M., Fallgatter, A.Cortical activation during two verbal fluency tasks in schizophrenic patients and healthy controls as assessed by multi-channel near-infrared spectroscopy. Psychiatr Res. 2007; 156(1): 1–13.CrossRefGoogle ScholarPubMed
Francey, S.M., Jackson, H.J., Phillips, L.J., Wood, S.J., Yung, A.R., McGorry, P.D.Sustained attention in young people at high risk of psychosis does not predict transition to psychosis. Schizophr Res 2005; 79: 127–136.CrossRefGoogle Scholar
Hambrecht, M., Lammertink, M., Klosterkotter, J., Matuschek, E., Pukrop, R.Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic. Br J Psychiatr. 2002; 181(suppl. 43): 30–37.CrossRefGoogle Scholar
Hawkins, K.A., Addington, J., Keefe, R.S.E., Christensen, B., Perkins, D.O., Zipursky, R.et al. Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophr Res 2004; 67: 115–122.CrossRefGoogle ScholarPubMed
Kay, S.R., Opler, S.A., Lindemeijer, J.P.The positive and Negative Symptom Scale: rationale and standardization. Br J Psychiat Suppl(7)1989 59–67.CrossRefGoogle Scholar
Klosterkotter, J., Hellmich, M., Steinmeyer, E.M., Schultze-Lutter, F.Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry. 2001; 58(2): 158–164.CrossRefGoogle ScholarPubMed
Lencz, T., Smith, C.W., Maclaughlin, D., Auther, A., Nakayama, E., Hovey, L.et al. Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatr 2006; 559: 863–871.CrossRefGoogle Scholar
Miller, T.J., McGlashan, T.H., Rosen, J.L., Somjee, L., Markovich, P.J., Stein, K.et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am J Psychiatr. 2002; 159(5): 863–865.CrossRefGoogle ScholarPubMed
Pukrop, R., Ruhrmann, S., Schultze-Lutter, F., Bechdolf, A., Brockhaus-Dumke, A., Klosterkotter, J.Neurocognitive indicators for a conversion to psychosis: Comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosis. Schizophr Res 2007; 92: 116–125.CrossRefGoogle Scholar
Ruiz-Veguilla, M., Gurpegui, M., Barrigón, M., Ferrín, M., Marín, E., Rubio, J.L.et al. Fewer neurological soft signs among first episode psychosis patients with heavy cannabis use. Schizophr Res 2009; 107: 158–164.CrossRefGoogle ScholarPubMed
Rund, B.A review of longitudal studies of cognitive functions in schizophrenia patients. Schizophr Res. 1998; 24(3): 425–435.CrossRefGoogle Scholar
Spitzer, R.L., Williams, J.B., Gibbon, M., First, M.B.The Structured Clinical Interview for DSM-III-R (SCID) I: History, rationale, and description. Arch Gen Psychiatr. 1992; 49(8): 624–629.CrossRefGoogle ScholarPubMed
Velthorst, E., Nieman, D.H., Becker, H.E., van de Fliert, R., Dingemans, P.M., Klaassen, R.et al. Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophr Res. 2009; 109(1-3): 60–65.CrossRefGoogle ScholarPubMed
Watanabe, A., Kato, T.Cerebrovascular response to cognitive tasks in patients with schizophrenia measured by near-infrared spectroscopy. Schizophr Bull 2004; 30: 435–444.CrossRefGoogle ScholarPubMed
Wood, S., Pantelis, C., Proffitt, T., Philips, L., Stuart, W., Buchanan, J.et al. Spatial working memory ability is a marker of risk for psychosis. Psychol Med 2003; 33: 1239–1249.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.