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The Taq IA polymorphism linked to the DRD2 gene is related to lower attention and less inhibitory control in alcoholic patients

Published online by Cambridge University Press:  16 April 2020

R. Rodríguez-Jiménez ,
C. Ávila ,
G. Ponce ,
M.I. Ibáñez ,
G. Rubio ,
M.A. Jiménez-Arriero ,
I. Ampuero ,
J.A. Ramos ,
J. Hoenicka  and
T. Palomo
R. Rodríguez-Jiménez*
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, Spain
C. Ávila
Affiliation:
Dpto. Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castelló, Spain
G. Ponce
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, Spain
M.I. Ibáñez
Affiliation:
Dpto. Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castelló, Spain
G. Rubio
Affiliation:
Servicios de Salud Mental, Retiro, Madrid, Spain
M.A. Jiménez-Arriero
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, Spain
I. Ampuero
Affiliation:
Facultad de Medicina, Universidad Complutense Madrid, Madrid, Spain
J.A. Ramos
Affiliation:
Facultad de Medicina, Universidad Complutense Madrid, Madrid, Spain
J. Hoenicka
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, Spain
T. Palomo
Affiliation:
Unidad de Conductas Adictivas (UCA), Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041Madrid, Spain
*
*Corresponding author. Tel.: +34 91 390 8022; fax: +34 91 390 8538. E-mail address:[email protected] (R. Rodríguez-Jiménez).
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Abstract

The TaqIA polymorphism linked to the DRD2 gene has been associated with alcoholism. The aim of this work is to study attention and inhibitory control as per the continuous performance test and the stop task in a sample of 50 Spanish male alcoholic patients split into two groups according to the presence of the TaqIA1 allele in their genotype. Our results show that alcoholics carrying the TaqIA1 allele present lower sustained attention and less inhibitory control than those patients without such allele.

Keywords

AlcoholismTaqIA polymorphismCPTStop taskAttentionInhibitory control
Type
Short communication
Information
European Psychiatry , Volume 21 , Issue 1 , January 2006 , pp. 66 - 69
Copyright
Copyright © Elsevier SAS 2006

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