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Soluble IL-6 receptors in the serum and cerebrospinal fluid of paranoid schizophrenic patients

Published online by Cambridge University Press:  16 April 2020

N Müller ,
P Dobmeier ,
M Empl ,
M Riedel ,
M Schwarz  and
M Ackenheil
N Müller
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
P Dobmeier
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
M Empl
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
M Riedel
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
M Schwarz
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
M Ackenheil
Affiliation:
Psychiatric Hospital, Nussbamstrasse 7, D-80336, Munich, Germany
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Summary

Soluble Interleukin-6 receptor (sIL-6R) levels are strongly related to the levels of Interleukin-6 (IL-6), and sIL-6Rs increase the immune activating properties of IL-6. We estimated sIL-6R serum levels in 25 schizophrenic patients and 25 healthy controls. In the patients, SIL-6R-CSF levels were also measured. The psychopathology was rated according to the AMDP system. We found a significant correlation between serum and cerebrospinal fluid (CSF) levels of sIL-6R, suggesting that serum levels may be a meaningful marker for the central action of sIL-6R. Moreover, significant correlations between the paranoid-hallucinatory syndrome and sIL-6R levels both in serum and CSF were observed. This finding suggests that IL-6 plays a role in the paranoid-hallucinatory symptomatology in schizophrenia. This can be understood regarding the influence of IL-6 to the catecholaminergic neurotransmission. The downregulating effects of neuroleptic treatment to sIL-6R demonstrate that the sIL-6R levels are decreased in the whole group of schizophrenic patients compared to controls.

Keywords

cytokinesInterleukin 6sIL-6Rschizophreniacerebrospinal fluid
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 6 , 1997 , pp. 294 - 299
Copyright
Copyright © European Psychiatric Association 1997

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