Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-19T10:48:26.338Z Has data issue: false hasContentIssue false
  • English
  • Français

A regression analytical approach to estimate the onset of activity of antidepressants

Published online by Cambridge University Press:  16 April 2020

H Müller  and
H-J Möller
H Müller
Affiliation:
Psychiatric department of the University Bonn
H-J Möller*
Affiliation:
Psychiatric department of the Ludwig-Maximilians-University Munich, Germany
*
*Correspondence and reprints: Psychiatric Hospital, Nussbaumstrasse 7, D-80336 Munich, Germany
Get access

Summary

The onset of activity of antidepressants is a clinically and theoretically important criterion of efficacy. We estimated the onset of activity by an intraindividual regression analytical approach. It is assumed that efficient treatment causes a fast shift of depression scores from a baseline level to an end level. From this assumption follows a limited number of opportunities for the onset of activity to occur. These opportunities correspond to different regression models which are estimated for each patient's depression course. The day of onset is concluded from the regression model which produces the best fit to the empirical depression curve. Results of a double-blind clinical trial comparing mianserin and amitriptyline are reported (n = 28). The methodological approach confirms that observer ratings by physicists show a significantly earlier onset of activity than self ratings by the patients. The D-S also shows a significantly earlier onset of activity of mianserin compared to amitriptyline. The discussion emphasises methodological aspects.

Keywords

depressionantidepressantsonset of efficacymethods
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue 3 , May 1998 , pp. 134 - 137
Copyright
Copyright © Elsevier, Paris 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Hamilton, MA Rating Scale for Depression J Neurol Neurosurg Psychiat 1960; 23: 56–62CrossRefGoogle ScholarPubMed
Jenner, FDSome of the problems and difficulties associated with clinical studies of antidepressant agents Br J Clin Pharmacol 1977; 4: 1993–2073CrossRefGoogle Scholar
Katz, MM, Koslow, SH, Maas, JW, et al.The timing, specificity and clinical prediction of tricyclic drug effects in depression Psychol Med 1987; 17: 297–309CrossRefGoogle ScholarPubMed
Lydiard, RB, Pottash, ALC, Gold, MSSpeed of onset of action of the newer antidepressants Psychopharmacol Bull 1984; 20: 258–271Google ScholarPubMed
Meya, UZum Konzept des “schnelleren Wirkeintritts” von Antidepressiva TW Psychiatrie 1990; 4: 831–840Google Scholar
Möller, H-J, Kasper, S, Müller, H, Kissling, W, Fuger, J, Ruhrmann, SA controlled study of the efficacy and safety of mianserin and amitriptyline in depressive inpatients Pharmacopsychiatry 1995; 28: 249–252CrossRefGoogle ScholarPubMed
Möller, H-J, Müller, H, Volz, H-PHow to assess the onset of antidepressant effect: comparison of global ratings and findings based on depression scales Pharmacopsychiatry 1996; 29: 57–62CrossRefGoogle ScholarPubMed
Quitkin, FM, Rabkin, G, Ross, D, Stewart, JWIdentification of true drug response to antidepressants Arch Gen Psychiatry 1984; 41: 782–786CrossRefGoogle Scholar
Quitkin, FM, Rabkin, G, Markowitz, JM, Stewart, JW, McGrath, PJ, Harrison, WUse of pattern analysis to identify true drug response Arch Gen Psychiatry 1987; 44: 259–264CrossRefGoogle ScholarPubMed
Rost, W, Schmidtke, A, Habner, CVK, Bauer, K, Gattaz, WFA comparison of the onset of action between maprotiline and fluvoxamine Psychopharmacology (D) 1988; 96: 145Google Scholar
Submit a response

Comments

No Comments have been published for this article.