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Reduced immobility time in the tail suspension test (TST) by chronic immobilization stress. Role of corticosterone and brain serotonergic and adrenergic receptors

Published online by Cambridge University Press:  16 April 2020

E De Castro-e-Silva ,
MF Peres ,
P Brito ,
C Cobas ,
A Saraiva ,
V Silva ,
A Chaves ,
L Barros  and
IR De Oliveira
E De Castro-e-Silva
Affiliation:
Laboratório de Neurociêncas
MF Peres
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
P Brito
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
C Cobas
Affiliation:
Laboratório de Neurociêncas
A Saraiva
Affiliation:
Laboratório de Neurociêncas
V Silva
Affiliation:
Laboratório de Neurociêncas
A Chaves
Affiliation:
Laboratório de Neurociêncas
L Barros
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
IR De Oliveira*
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
*
*Correspondence and reprints.
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Summary

Chronically stressed adult male Balb C mice were submitted to the tail suspension test. Chronic immobilization stress (6 h/d for 14 consecutive days) induced a significant reduction in immobility time when compared to non-stressed controls. Pretreatment with LY 53857, a serotonin 5HT2 antagonist, and IPS 339, a selective beta-2 adrenoceptor blocker, reversed immobility time to the levels of non-stressed controls. Chronic administration of corticosterone (100 mg/kg for 7 d) did not modify immobility time as compared to saline treated controls. It is suggested that both serotonergic and adrenergic pathways in the brain may participate in the stress-induced changes occurring in the tail suspension test response and that corticosterone does not appear to play a role in this process.

Keywords

tail suspension teststressserotoninnoradrenalinecorticosterone
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 5 , 1992 , pp. 235 - 238
Copyright
Copyright © Elsevier, Paris 1992

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