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Proton magnetic resonance spectroscopy (1H-MRS) of the thalamus in schizophrenia

Published online by Cambridge University Press:  16 April 2020

P Delamillieure ,
J.M Constans ,
J Fernandez ,
P Brazo  and
S Dollfus
P Delamillieure
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
J.M Constans
Affiliation:
Centre IRM, Centre Hospitalier et Universitaire, 14000Caen, France
J Fernandez
Affiliation:
Centre IRM, Centre Hospitalier et Universitaire, 14000Caen, France
P Brazo
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
S Dollfus*
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
*
*Correspondence and reprints. Email address: [email protected] (S. Dollfus).
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Extract

This study applied 1H-MRS in the thalamus of schizophrenic patients and healthy subjects.

There were no differences in the metabolite ratios (NAA/Cr, Cho/Cr or mI/Cr) between the two groups. Relationships were noted between NAA/Cr and age in patients with a trend toward this correlation in controls, suggesting an effect of age on the metabolism of the thalamus.

Keywords

agingN-acetyl-aspartateschizophreniaspectroscopythalamus
Type
Short Communication
Information
European Psychiatry , Volume 15 , Issue 8 , December 2000 , pp. 489 - 491
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

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References

Andreasen, NCArndt, SSwayze, V.W.I.ICizadlo, TFlaum, MO’Leary, D et al. Thalamic abnormalities in schizophrenia visualized through schizophrenia: a proton magnetic resonance spectroscopic imaging study Biol Psychiatry 1998; 43: 641–648Google Scholar
Bertolino, ACallicott, JHElman, IMattay, VSTedeschi, GFrank, JA et al. Regionally specific neuronal pathology in untreated patients with schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging Am J Psychiatry 1996; 153: 1554–1563Google Scholar
Bertolino, ANawroz, SMattay, VSBarnett, ASDuyn, JHMoonen, C.T.W et al. Regionally specific pattern of neurochemical pathology in magnetic resonance image averaging Science 1994; 266: 294–298Google Scholar
Charles, HCLazeyras, FKrishnan, KRBoyko, OBPatterson, LJDoraiswamy, PM et al. Proton spectroscopy of human brain: effects of age and sex Prog Neuropsychopharmacol Biol Psychiatry 1994; 18: 9995–10004CrossRefGoogle ScholarPubMed
Deicken, RFJohnson, CEliaz, YSchuff, NReduced concentrations of thalamic N-acetyl-aspartate in male patients with schizophrenia Am J Psychiatry 2000; 157: 644–647CrossRefGoogle ScholarPubMed
Fukuzako, HHashiguchi, TSakamoto, YOkamura, HDoi, WTakenouchi, K et al. Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects Psychiatry Clin Neurosci 1997; 51: 261–263CrossRefGoogle ScholarPubMed
Hazlett, EABuchsbaum, MSByne, WWei, TCSpiegel-Cohen, JGeneve, C et al. Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum Am J Psychiatry 1999; 156: 1190–1199Google ScholarPubMed
Lim, KOAdalsteinsson, ESpielman, DSullivan, EVRosenbloom, MJProton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia Arch Gen Psychiatry 1998; 55: 346–352CrossRefGoogle Scholar
Omori, MPearce, JKomoroski, RAGriffin, STMrak, REHusain, MM et al. In vitro 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia Biol Psychiatry 1997; 42: 359–366CrossRefGoogle ScholarPubMed
Pakkenberg, BPronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics Arch Gen Psychiatry 1990; 47: 1023–1028CrossRefGoogle ScholarPubMed
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