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Preference of medicine and patient-reported quality of life in community-treated schizophrenic patients receiving aripiprazole vs standard of care: Results from the STAR study

Published online by Cambridge University Press:  16 April 2020

David Taylor ,
Linda Hanssens ,
Jean-Yves Loze ,
Miranda Pans ,
Gilbert L'Italien  and
Ronald N. Marcus
David Taylor*
Affiliation:
South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, LondonSE5 8AZ, UK School of Biomedical Sciences, King's College, London
Linda Hanssens
Affiliation:
Bristol-Myers Squibb Company, Braine-l'Alleud, Belgium
Jean-Yves Loze
Affiliation:
Otsuka Pharmaceutical France SAS, Paris, France
Miranda Pans
Affiliation:
Bristol-Myers Squibb Company, Braine-l'Alleud, Belgium
Gilbert L'Italien
Affiliation:
Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA
Ronald N. Marcus
Affiliation:
Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA
*
*Corresponding author. South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London SE5 8AZ, UK. Tel.: +44 (0)20 3228 5040; fax: +44 (0)20 3228 5279. E-mail addresses: [email protected] (D. Taylor), [email protected] (L. Hanssens), [email protected] (J.-Y. Loze), [email protected] (M. Pans), [email protected] (G. L'Italien), [email protected] (R.N. Marcus).
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Abstract

Objective

To evaluate quality of life and patient preference for schizophrenia treatment in a community based study comparing the use of aripiprazole to the standard of care (SOC).

Method

This open-label, 26-week, multi-centre, randomised study compared aripiprazole with SOC (olanzapine, quetiapine or risperidone) in patients with schizophrenia (DSM-IV-TR criteria). The primary effectiveness variable was the mean total score of the Investigator Assessment Questionnaire (IAQ) at Week 26. The outcome research variables included the Preference of Medicine (POM) questionnaire, the Quality of Life Scale (QLS), and the EuroQoL-5D (EQ-5D). The results from these outcome research variables are the focus of this paper addressing quality of life and patient preference.

Results

A total of 555 patients were randomised to receive aripiprazole (n = 284) or SOC (n = 271). The OC data at Week 26, reported that more respondents rated the study medication as ‘much better’ compared with their previous medication in the aripiprazole group versus SOC for patients (59% vs 35%, P < 0.001) and caregivers (58% vs 30%, P = 0.014). The improvement in QLS total score was also significantly greater in the aripiprazole group compared with SOC – mean change from baseline in QLS total score of 16.21 vs 10.01 (P < 0.001) at Week 26 (OC data set). A greater proportion of patients (93% vs 85%; P = 0.005) in the aripiprazole group had a satisfactory response on the EQ-5D Self Care Scale; all other EQ-5D scores were similar.

Conclusion

The study findings suggest that quality of life and patient medication preference measures were better for aripiprazole than for SOC.

Keywords

SchizophreniaAripiprazoleAtypical antipsychoticNaturalistic studyQuality of lifePatient preference
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 5 , August 2008 , pp. 336 - 343
Copyright
Copyright © Elsevier Masson SAS 2008

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Footnotes

1

Tel.: +32 2 352 7152; fax: +32 2 352 7887.

2

Tel.: +33 1 4708 0000; fax: +33 1 4751 8809.

3

Tel.: +32 2 352 7740; fax: +32 2 352 7800.

4

Tel.: +1 203 677 6572; fax: +1 203 677 5797.

5

Tel.: +1 203 677 6763; fax: +1 203 677 7695.

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