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Platelet counts in depressed patients treated with amitriptyline or paroxetine

Published online by Cambridge University Press:  16 April 2020

F. Lederbogen ,
E. Hörer ,
R. Hellweg ,
I. Heuser  and
M. Deuschle
F. Lederbogen*
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
E. Hörer
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
R. Hellweg
Affiliation:
Department of Psychiatry, Free University, Berlin, Germany
I. Heuser
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany Department of Psychiatry, Free University, Berlin, Germany
M. Deuschle
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
*
*E-mail address: [email protected]
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Abstract

Objective

To assess whether therapy with two widely used antidepressants influences platelet counts.

Subjects and methods

In 90 patients hospitalized for treatment of a major depressive episode according to DSM-IV, platelet counts were performed after a 6 d antidepressant-free run-in period and again after 35 d of active standardized treatment with amitriptyline (n = 40) or paroxetine (n = 50).

Results

There was a trend for platelet counts to increase during treatment with amitriptyline (from 245.5 ± 68.6 to 256.8 ± 69 cells × 109 L-1, P < 0.06); no change was observed during treatment with paroxetine (from 232.6 ± 58.3 to 234.6 ± 68.9 cells × 109 L-1, n.s).

Conclusions

Treatment with amitriptyline tends to be associated with elevated platelet counts. The cause for this increase is not known, but may be relevant in terms of patients’ long-term thromboembolic risk.

Keywords

Platelet countDepressionAntidepressant
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 2 , March 2003 , pp. 89 - 91
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2002

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