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Personality traits in treated Wilson’s disease determined by means of the Karolinska Scales of Personality (KSP)

Published online by Cambridge University Press:  16 April 2020

K. Portala ,
K. Westermark ,
L. Ekselius  and
L. von Knorring
K. Portala*
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, SE-751 85Uppsala, Sweden
K. Westermark
Affiliation:
Department of Internal Medicine, Uppsala University Hospital, SE-751 85Uppsala, Sweden
L. Ekselius
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, SE-751 85Uppsala, Sweden
L. von Knorring
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University Hospital, SE-751 85Uppsala, Sweden
*
* Correspondence and reprints. E-mail address: [email protected] (K. Portala).
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Summary

Objective

The aim was to elucidate the personality traits of patients with treated Wilsonˈs disease (WD) in comparison to healthy volunteers.

Method

Twenty-five WD patients, ten females and 15 males, with a mean age of 35.2 ± 8.3 years completed the Karolinska Scales of Personality (KSP), a self-report inventory comprising 15 separate scales. The results were compared to a control series comprising 200 men and 200 women drawn from the general population.

Results

The patients with treated WD scored significantly lower than the healthy controls on aggressivity-hostility-related scales and the scale measuring Psychic Anxiety. Patients with predominantly hepatic symptoms had the lowest aggressivity-related scores and patients with predominantly neurological symptoms had the lowest Irritability, Guilt and Detachment scores and the highest Impulsiveness and Muscular Tension scores. Both groups scored low on the Somatic Anxiety scale.

Conclusion

The present results illustrate that patients with treated WD have significant deviations in personality traits, especially in aggressivity-hostility-related scales and Psychic Anxiety, compared to healthy controls when investigated by means of a self-report inventory, the KSP. The deviations were not related to age, age at onset or duration of the disease.

Keywords

hepatolenticular degenerationKarolinska scales of personalitypersonality traitsWilson’s disease
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 6 , September 2001 , pp. 362 - 371
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

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References

Af Klinteberg, BSchalling, DEdman, GOreland, LÅsberg, M.Personality correlates of platelet monoamine oxidase (MAO) activity in female and male subjects. Neuropsychobiology 1987; 18: 89–96.CrossRefGoogle ScholarPubMed
Akil, MSchwartz, JADutchak, DYuzbasiyan-Gurkan, VBrewer, GJ.The psychiatric presentations of Wilson's disease. J Neuropsychiatry Clin Neurosci 1991; 3: 377–82.Google ScholarPubMed
Bergman, HBergman, IEngelbrektsson, KHolm, LJohannesson, KLindberg, S.Psykologhandboken vid Magnus Huss-kliniken. Stockholm: Karolinska sjukhuset; 1982.Google Scholar
Björvell, HHylander, B.Functional status and personality in patients on chronic dialysis. J Inter M 1989; 226: 319–24.CrossRefGoogle ScholarPubMed
Bull, PCThomas, GRRommens, JMForbes, JRCox, DW.The Wilson disease gene is a putative copper transporting P-type APTase similar to the Menkes gene. Nat Genet 1993; 5: 327–37.CrossRefGoogle Scholar
Cummings, JL.Frontal-subcortical circuits and human behavior. Review. Arch Neurol 1993; 50: 873–80.CrossRefGoogle ScholarPubMed
Dabbs, JMFrady, RLCarr, TSBesch, NF.Saliva testosterone and criminal violence in young adult prison inmates. Psychosom M 1987; 49: 174–82.CrossRefGoogle ScholarPubMed
Dahlman, THartvig, PLöfholm, MNordlinger, HLööf, LWestermark, K.Long-term treatment of Wilson's disease with triethylene tetramine dihydrochloride (trientine). Q J M 1995; 88: 609–16.Google Scholar
Dening, TRBerrios, GB.Wilson's disease: a prospective study of psychopathology in 31 cases. Br J Psychiatry 1989; 155: 206–13.CrossRefGoogle ScholarPubMed
Dening, TRBerrios, GE.Wilson's disease. Psychiatric symptoms in 195 cases. Arch Gen Psychiatry 1989; 46: 1126–34.CrossRefGoogle ScholarPubMed
Dening, TRBerrios, GE.Wilson's disease: clinical groups in 400 cases. Acta Neurol Scand 1989; 80: 527–34.CrossRefGoogle ScholarPubMed
Earl, CJ.Anatomical distribution of copper in the brain. Cummings, JMWalshe, JN, Eds.; Wilson's disease: some current concepts. Oxford: Blackwell; 1961.Google Scholar
Eriksson, ESundblad, CLisjö, PModigh, KAndersch, B.Serum levels of androgens are higher in women with premenstrual irritability and dysphoria than in controls. Psychoneuroendocrinology 1992; 17: 195.CrossRefGoogle ScholarPubMed
Farde, LGustavsson, JPJönsson, E.D2 dopamine receptors and personality traits [〚letter] Nature 1997; 385: 590.CrossRefGoogle Scholar
Frydman, MKauschansky, ABonne-Tamir, BNassar, FHomburg, R.Assessment of hypothalamic-pituitary-testicular function in male patients with Wilson's disease. J Androl 1991; 12: 180–4.Google ScholarPubMed
Goldstein, NPEwert, JCRandall, RVGross, JB.Psychiatric aspects of Wilson's disease (hepatolenticular degeneration): results of psychometric tests during long-term therapy. Am J Psychiatry 1968; 124: 1155–61.CrossRefGoogle ScholarPubMed
Gollan, JLGollan, TJ.Wilson's disease in 1998: genetic, diagnostic and therapeutic aspects. J Hepatol 28Suppl 11998 28–36.CrossRefGoogle ScholarPubMed
Gustavsson, JP.Stability and validity of self-reported personality traits. [dissertation] Stockholm: Karolinska Institute; 1997.Google Scholar
Hawkins, RAMazziotta, JCPhelps, ME.Wilson's disease studied with FDG and positron emission tomography. Neurology 1987; 37: 1707–11.CrossRefGoogle ScholarPubMed
Helleday, JEdman, GRitzén, EMSiwers, B.Personality characteristics and MAO activity in women with congenital adrenal hyperplasia (CAH). Psychoneuroendocrinology 1993; 18: 343–54.CrossRefGoogle Scholar
Hoogenraad, T.Wilson's disease. Warlow, CPvon Gijn, J, Eds.; Major problems in neurology, Vol 30. London: WB Saunders; 1995. 107–8.Google Scholar
Horoupian, DSSternlieb, IScheinberg, IH.Neuropathological findings in penicillamine-treated patient with Wilson's disease. Clin Neuropathol 1988; 7: 62–7.Google ScholarPubMed
Jeon, BKim, JMJeong, JMKim, KMChang, YSLee, SD., et al. Dopamine transporter imaging with 〚123 I〛-ß -CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease. J Neurol Neurosurg Psychiatry 1998; 65: 60–4.CrossRefGoogle Scholar
Kaushansky, AFrydman, MKaufman, HHomburg, R.Endocrine studies of ovulatory disturbance in Wilson's disease (hepatolenticular degeneration). Fertil Steril 1987; 47: 270–3.CrossRefGoogle Scholar
Laakso, AVilkman, HKajander, JBergman, JHaaparanta, MSolin, O., et al. Prediction of detached personality in healthy subjects by low dopamine transporter binding. Am J Psychiatry 2000; 2: 290–2.CrossRefGoogle Scholar
Oder, WPrayer, LGrimm, GSpatt, JFerenci, PKollegger, H., et al. Wilson's disease: evidence of subgroups derived from clinical findings and brain lesions. Neurology 1993; 43: 120–4.CrossRefGoogle ScholarPubMed
Oertel, WHTatsch, KSchwartz, JKraf, ETrenkwalder, CScherer, J., et al. Decrease of D2 receptors indicated by 123 I-Iodobenzamide single-photon emisson computed tomography relates to neurological deficit in treated Wilson's disease. Ann Neurol 1992; 32: 743–8.CrossRefGoogle Scholar
Nyberg, PGottfries, C-G.Holmgren, GPersson, SRoos, B-E.Winblad, B.Advanced catecholaminergic disturbances in the brain in a case of Wilson's disease. Acta Neurol Scand 1982; 65: 71–5.CrossRefGoogle Scholar
Perris, CEisemann, MEriksson, U., et al. Variations in self-assessment of personality characteristics in depressed patients, with special reference to aspects of aggression. Psychiatr Clin 1979; 12: 209–15.Google ScholarPubMed
Portala, KWestermark, Kvan Knorring, LEkselius, L.Psychopathology in treated Wilson’s disease determined by means of CPRS expert and self-ratings. Acta Psychiatr Scand 2000; 101: 104–9.CrossRefGoogle ScholarPubMed
Schalling, D.Neurochemical correlates of personality, impulsivity, and disinhibitory suicidality. Hodgins, S, Ed.; Mental disorder and crime. 1st Newbury Park 〚CA〛: SAGE Publication; 1993. 208–26.Google Scholar
Schalling, DÅsberg, MEkman, GOreland, L.Markers for vulnerability to psychopathology: temperament traits associated with platelet MAO activity. Acta Pstchiatr Scand 1987; 76: 172–82.CrossRefGoogle ScholarPubMed
Scheinberg, IHSternlieb, I.Wilson's disease. Smith, LH Jr., Ed.; Major problems in internal medicine. Vol XXIII. Philadelphia: WB Saunders Co.; 1984.Google Scholar
Snow, BJBhatt, MMartin, WRWLi, DCalne, DB.The nitrostriatal dopaminergic pathway in Wilson's disease studied with positron emission tomography. J Neurol Neurosurg Psychiatry 1991; 54: 12–7.CrossRefGoogle Scholar
Thuomas, KÅAquilonius, SMBergström, KWestermark, K.Magnetic resonance imaging of the brain in Wilson's disease. Neuroradiology 1993; 35: 134–41.CrossRefGoogle ScholarPubMed
Von Knorring, LPerris, CEisemann, MEriksson, UPerris, H.Pain as a symptom in Depressive disorder. II. Relationship to personality traits as assessed by means of KSP. Pain 1983; 17: 377–84.CrossRefGoogle ScholarPubMed
Von Knorring, LPerris, CEisemann, MPerris, H.Discrimination of former depressed patients from healthy volunteers on the basis of stable personality traits assessed by means of KSP. Eur Arch Psychiatr Neurol Sci 1984; 234: 202–5.CrossRefGoogle ScholarPubMed
Von Knorring, LAlmay, BGLJohansson, F.Personality traits in patients with idiopathic pain disorder. Acta Psychiatr Scand 1987; 76: 490–8.CrossRefGoogle ScholarPubMed
Waldenström, ELagerkvist, ADahlman, TWestermark, KLandegren, U.Efficient detection of mutations in Wilson disease by manifold sequencing. Genomics 1996; 37: 303–9.CrossRefGoogle ScholarPubMed
Walker, S.The psychiatric presentation of Wilson's disease (hepatolenticular degeneration) with an etiologic explanation. Behav Neuropsychiatry 1969; 1: 38–43.Google ScholarPubMed
Walsh, JMGibbs, KR.Brain copper in Wilson's disease. Lancet II 1987 1030.CrossRefGoogle Scholar
Westermark, KTedroff, JThuomas, KÅHartvig, PLångström, BAndersson, Y., et al. Neurological Wilson's disease studied with magnetic resonance imaging and with positron emission tomography using dopaminergic markers. Mov Disord 1995; 10: 596–603.CrossRefGoogle ScholarPubMed
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