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Persistent cerebellar deterioration in a patient with lobar pneumonia under lithium, carbamazepine, and trifluperidol treatment

Published online by Cambridge University Press:  16 April 2020

F Bischof ,
A Melms  and
M Fetter
F Bischof
Affiliation:
Department of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands
A Melms
Affiliation:
Department of Neurology, University of Tübingen, Tübingen, Germany
M Fetter
Affiliation:
Department of Neurology, University of Tübingen, Tübingen, Germany
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Summary

We report on a patient with schizoaffective disorder who was on combination therapy of lithium, carbamazepine, and the neuroleptic trifluperidol. He experienced a lobar pneumonia and developed an acute and persistent cerebellar deterioration which was most likely due to lithium toxicity, while the serum lithium level was within the therapeutic range. The combination of lithium, carbamazepine, and neuroleptics is common, and is generally considered to be safe. The reported case suggests that this regimen might increase the risk of intoxication with potentially disabling side-effects.

Keywords

affective disordercarbamazepinecerebellumlithiumneurolepticstoxicity
Type
Case Reports
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 175 - 176
Copyright
Copyright © European Psychiatric Association 1999

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References

Cohen, WJ, Cohen, NHLithium carbonate, haloperidol, and irreversible brain damage. JAMA 1974 ; 230 : 1283–1287.CrossRefGoogle ScholarPubMed
Freeman, MP, Stoll, ALMood stabilizer combinations: a review of safety and efficacy. Am J Psychiatry 1998 ; 155 : 12–21.CrossRefGoogle ScholarPubMed
Mani, J, Tandel, SV, Shah, PU, Karnad, DRProlonged neurological sequelae after combination treatment with lithium and antipsychotic drugs [letter]. J Neurol Neurosurg Psychiatry 1996 ; 60 : 350–351.CrossRefGoogle Scholar
Nagaraja, D, Taly, AB, Sahu, RN, Channabasavanna, SM, Narayanan, HSPermanent neurological sequelae due to lithium toxicity. Clin Neurol Neurosurg 1987 ; 89 : 31–34.CrossRefGoogle ScholarPubMed
Pheterson, AD, Miller, L, Fox, CF, Estroff, TW, Sweeney, DRMultifocal neurological impairment caused by infection-induced rise in blood lithium and amitriptyline. Int J Psychiatry M 1986 ; 16 : 257–262.CrossRefGoogle ScholarPubMed
Schneider, JA, Mirra, SSNeuropathologic correlates of persistent neurologic deficit in lithium intoxication. Ann Neurol 1994 ; 36 : 928–931.CrossRefGoogle ScholarPubMed
Shukla, S, Godwin, CD, Long, LE, Miller, MGLithium-carbamazepine neurotoxicity and risk factors. Am J Psychiatry 1984 ; 141 : 1604–1606.Google ScholarPubMed
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