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Patient outcomes in schizophrenia I: correlates with sociodemographic variables, psychopathology, and side effects

Published online by Cambridge University Press:  16 April 2020

Alex Hofer ,
Susanne Baumgartner ,
Monika Edlinger ,
Martina Hummer ,
Georg Kemmler ,
Maria A. Rettenbacher ,
Hansjoerg Schweigkofler ,
Josef Schwitzer  and
W. Wolfgang Fleischhacker
Alex Hofer*
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Susanne Baumgartner
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Monika Edlinger
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Martina Hummer
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Georg Kemmler
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Maria A. Rettenbacher
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Hansjoerg Schweigkofler
Affiliation:
Department of General Psychiatry, General Hospital Bressanone, Bressanone, Italy
Josef Schwitzer
Affiliation:
Department of General Psychiatry, General Hospital Bressanone, Bressanone, Italy
W. Wolfgang Fleischhacker
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
*
*
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Abstract

Objective

The present cross-sectional study examined the relationships of psychopathology, side effects, and sociodemographic factors with treatment outcomes in terms of patients' quality of life (QOL), functioning, and needs for care.

Method

Sixty outpatients with chronic schizophrenia who had been treated with either clozapine or olanzapine for at least 6 months were investigated.

Results

Most psychopathological symptoms as well as psychic side effects, weight gain, and female sex were associated with lower QOL, while cognitive symptoms correlated with better QOL. Female sex, cognitive symptoms, and parkinsonism negatively influenced occupational functioning, and negative symptoms determined a lesser likelihood of living independently. Age, education, depression/anxiety, negative symptoms, and psychic side effects were predictors of patients' needs for care.

Conclusion

Our results highlight the complex nature of patient outcomes in schizophrenia. They reemphasize the need of targeting effectiveness, i.e. both symptomatic improvement as well as drug safety, in such patients.

Keywords

SchizophreniaOutcomeNeedsQuality of lifeEmployment
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 5-6 , August 2005 , pp. 386 - 394
Copyright
Copyright ©Elsevier SAS 2005

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