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P300 event-related potential and serotonin-1A activity in depression

Published online by Cambridge University Press:  16 April 2020

M Hansenne  and
M Ansseau
M Hansenne
Affiliation:
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium
M Ansseau
Affiliation:
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium
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Summary

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

Keywords

depressionflesinoxan testP300serotonin-1A
Type
Original Articles
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 143 - 147
Copyright
Copyright © European Psychiatric Association 1999

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