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Obstetric complications in distinct schizophrenic subgroups

Published online by Cambridge University Press:  16 April 2020

G Stöber ,
E Franzek  and
H Beckmann
G Stöber
Affiliation:
Department of Psychiatry, University of Wuerzburg, Fuechsleinstr 15, G-97080Wuerzburg, Germany
E Franzek
Affiliation:
Department of Psychiatry, University of Wuerzburg, Fuechsleinstr 15, G-97080Wuerzburg, Germany
H Beckmann
Affiliation:
Department of Psychiatry, University of Wuerzburg, Fuechsleinstr 15, G-97080Wuerzburg, Germany
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Summary

In 55 chronic DSM III-R schizophrenics the occurrence of obstetric complications (OCs) was investigated using the familial/sporadic strategy and Leonhard's unsystematic/systematic distinction. The overall frequency and severity of OCs did not differ between patients and controls. A sub-sample of patients, whose genetic risk was supposed to be high in both classification systems (diagnosis of unsystematic and familial schizophrenia), had significantly fewer OCs than controls on the Lewis and Murray scale (P < 0.05). With reference to previous reports of increased mortality rates in the offspring of schizophrenics, high genetic risk and additional perinatal stressors may increase perinatal mortality. In contrast, patients whose genetic risk was supposed to be low in both systems (diagnosis of systematic and sporadic schizophrenia) showed a trend to an increased frequency of OCs in the Fuchs scale. In the context of the recently reported highly significantly increased rate of maternal infections during midgestation in these patients, it was supposed that perinatal complications may be of some aetiological importance in schizophrenics with low genetic risk.

Keywords

obstetric complicationsschizophreniafamilial-sporadic conceptLeonhard classification
Type
Original article
Information
European Psychiatry , Volume 8 , Issue 6 , 1993 , pp. 293 - 299
Copyright
Copyright © Elsevier, Paris 1993

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