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Neurochemical variables in subjects with adjustment disorder after suicide attempts
Published online by Cambridge University Press: 16 April 2020
Summary
The investigation of biological correlates of suicidal behavior is important for identifying high-risk subjects. The objective of this study was to examine the neurochemical variables' platelet MAO activity and urinary MHPG, 5HIAA and HVA, the main metabolites of noradrenaline, serotonin and dopamine, neurotransmitters that are considered to be involved in the pathophysiology of suicidal behavior, as well as plasma cortisol, in a group of subjects with adjustment disorder after a suicide attempt. Fifty-three patients, 42 females and 11 males, were included in the study and were compared to a group of 50 healthy controls, 25 females and 25 males. Platelet MAO activity was found to be significantly lower in both male and female patients compared to controls of the same sex (P < 0.001 for both comparisons). 5HIAA and HVA were not different between patients and controls, but MHPG was significantly higher in the patients group (P = 0.008). Moreover, plasma levels of cortisol were significantly higher in the patients compared to the controls (P < 0.001). Our results confirm the hypothesis of low platelet MAO activity as a biological characteristic of patients who attempt suicide. They also point to a possible parallel activation of the noradrenergic system.
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References
Agren, H.Depressive symptom patterns and urinary MHPG excretion Psychiatry Res 6 1982 185–196CrossRefGoogle ScholarPubMed
American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Rev Washington, DCAmerican Psychiatric Press 1987Google Scholar
Andreasen, N.C.Hoenk, P.R.The predictive value of adjustment disorder: a follow-up study Am J Psychiatry 139 1982 584–590Google ScholarPubMed
Asberg, M.Schalling, D.Traskman-Bendz, L.Wagner, A.Psychobiology of suicide, impulsivity, and related phenomenaMeltzer, HPsychopharmacology: the third generation of progress New YorkRaven Press 1987 655–668Google Scholar
Asnis, G.M.Friedman, T.A.Sanderson, W.C.Kaplan, M.L.Van Praag, H.M.Harkavy-Friedman, J.M. et al. Suicidal behaviors in adult psychiatric outpatients. I. Description and prevalence Am J Psychiatry 150 1993 108–112Google ScholarPubMed
Banki, C.M.Arato, M.Papp, Z.Kurcz, M.Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests J Affect Disorders 6 1984 341–350CrossRefGoogle ScholarPubMed
Beck, A.T.Beck, R.Kovacs, M.Classification of suicidal behaviors. I. Quantifying intent and lethality Am J Psychiatry 132 1975 282–287Google ScholarPubMed
Beckmann, H.Goodwin, F.K.Urinary MHPG in subgroups of depressed patients and normal controls Neuropsychobiology 6 1980 90–91CrossRefGoogle ScholarPubMed
Bronisch, T.Hecht, H.Validity of adjustment disorder, comparison with major depression J Affect Disorders 17 1989 229–236CrossRefGoogle ScholarPubMed
Braunig, P.Pollentier, S.Rao, M.L.Increased serotonin after a suicide attempt: coincidence or catharsis Biol Psychiatry 24 1988 721–724CrossRefGoogle ScholarPubMed
Buchsbaum, M.S.Coursey, R.D.Murphy, D.L.The biochemical high risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity Science 194 1976 339–341CrossRefGoogle ScholarPubMed
Cobbin, D.M.Requin-Blow, B.Williams, L.R.Williams, W.O.Urinary MHPG levels and tricyclic antidepressant drug selection A preliminary communication on improved drug selection in clinical practice. Arch Gen Psychiatry 36 1979 1111–1115Google ScholarPubMed
Eckert, B.Gottfries, C.G.Von Knorring, L.Oreland, L.Wiberg, A.Winblad, B. et al. Brain and platelet monoamine oxidase in mental disorders. I. Schizophrenics and cycloid psychotics Prog Neuropsychopharmacol Biol Psychiatry 4 1980 57–68Google ScholarPubMed
Fabrega, H.Mezzich, J.E.Mezzich, A.C.Adjustment disorder as a marginal or transitional illness category in DSM-III Arch Gen Psychiatry 44 1987 567–572CrossRefGoogle ScholarPubMed
Fowler, C.J.Oreland, L.Callingham, B.A.The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications J Pharm Pharmacol 33 1981 341–347CrossRefGoogle ScholarPubMed
Greenberg, W.M.Rosenfeld, D.N.Ortega, E.A.Adjustment disorder as an admission diagnosis Am J Psychiatry 152 1995 459–461Google ScholarPubMed
Gupta, B.Trzepacz, P.T.Serious overdoses admitted to a general hospital: comparison with non-overdose self-injuries and medically ill patients with suicidal ideation Gen Hosp Psychiatry 19 1997 209–215CrossRefGoogle Scholar
Mancini, C.Brown, G.M.Urinary catecholamines and cortisol in parasuicide Psychiatr Res 43 1992 31–42CrossRefGoogle ScholarPubMed
Murphy, D.L.Wright, C.Buchsbaum, M.S.Nichols, A.Costa, J.L.Wyatt, R.J. et al. Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time Biochem M 16 1976 254–265CrossRefGoogle Scholar
Pedersen, N.L.Oreland, L.Reynolds, C.Mc Clean, G.E.Importance of genetic effects for monoamine oxidase activity in thrombocytes in twins apart and twins reared together Psychiatry Res 46 1993 239–251CrossRefGoogle ScholarPubMed
Pichot, W.Aussean, M.Gonzalez, Moreno, A.Wauthy, J.Hansenne, M. et al. Relationship between alpha-2-adrenergic function and suicidal behavior in depressed patients Psychiatry Res 52 1994 115–123CrossRefGoogle Scholar
Pichot, W.Hansenne, M.Conzalez Moreno, A.Aussean, M.Growth hormone response to clonidine in nondepressed patients with a history of suicide attempts Biol Psychiatry 38 1995 201–203CrossRefGoogle Scholar
Pivac, N.Jakovljevic, M.Muck-Seler, D.Brzovic, Z.Hypothalamic-Pituitary-Adrenal axis function and platelet serotonin concentrations in depressed patients Psychiatr Res 73 1997 123–132CrossRefGoogle ScholarPubMed
Roy, A.De Jong, J.Linnoila, M.Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study Arch Gen Psychiatry 46 1989 609–612CrossRefGoogle ScholarPubMed
Roy, A.Karoum, F.Pollack, S.Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide Arch Gen Psychiatry 49 1992 447–450CrossRefGoogle ScholarPubMed
Roy, A.Hypothalamic-Pituitary-Adrenal axis function and suicidal behavior in depression Biol Psychiatry 32 1992 812–816CrossRefGoogle ScholarPubMed
Runeson, B.Mental disorder in youth suicide. DSM-III-R Axes I and II Acta Psychiatr Scand 79 1989 490–497CrossRefGoogle ScholarPubMed
Schalling, D.Asberg, M.Edman, G.Oreland, L.Markers for vulnerability to psychopathology: temperament traits associated with platelet MAO activity Acta Psychiatr Scand 76 1987 172–182CrossRefGoogle ScholarPubMed
Secunda, S.Cross, C.Koslow, S.Katz, M.Kocsis, J.Maas, J. et al. Biochemistry and suicidal behavior in depressed patients Biol Psychiatry 21 1986 756–767CrossRefGoogle ScholarPubMed
Tripodianakis, J.Markianos, M.Sarantidis, D.Istikoglou, C.Andara, A.Bistolaki, E. et al. Platelet monoamine oxidase in attempted suicide. Relations to sex, psychiatric diagnosis, mode of attempt and previous attempts Eur Psychiatry 10 1995 44–48CrossRefGoogle ScholarPubMed
Tripodianakis, J.Sarantidis, D.Theodoropoulou, S.Priami, M.Jialouris, A.Pachi, E.An epidemiological and clinical study of 838 suicide attempts in Evangelismos General Hospital Psychiatriki 4 1993 153–158Google Scholar
Van Praag, H.M.Biological suicide research: outcome and limitations Biol Psychiatry 21 1986 1305–1323CrossRefGoogle ScholarPubMed
Van Praag, H.Plutchik, R.An empirical study on the cathartic effect of attempted suicide Psychiatry Res 16 1985 123–130CrossRefGoogle Scholar
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